Department of Chemestry
Short biography and Publications by Reinhard Bredehorst
Short biography
| 1946 | born in Hamburg |
| 1975 | Approbation as a doctor |
| 1975 | Promotion (Dr. med.) with Helmuth Hilz |
| 1979 | G. E. Konjetzny Prize for "Scientific Work in Cancer Research |
| 1982 | Dr. Martini Award for "scientific work on postsynthetic protein modifications". |
| 1983 | Habilitation and award of the Venia Legendi for the subject of Physiological Chemistry in the Department of Medicine at the University of Hamburg |
| 1984 | Recognition as a specialist in laboratory medicine |
| 1984-1987 | Assistant Professor of Biochemistry and Molecular Biology at Georgetown University in Washington, DC, USA. |
| 1987-1991 | Associate Professor of Biochemistry and Molecular Biology at Georgetown University in Washington, DC, USA. |
| 1988 | Alan Berman Research Award for "scientific work on immunoassays". |
| 1991-2011 | Professor of Biochemistry at the University of Hamburg |
| 1991-1996 | Adjunct Professor of Biochemistry and Molecular Biology at Georgetown University in Washington, DC, USA. |
| 1996 | Child Philipp Prize for Pediatric Hematology and Oncology |
| 1998 | Recognition as a specialist in biochemistry |
| 2004- | Founding member and scientific director of the company PLS Design GmbH |
| 2016- | Founding member and scientific director of the company Tolerogenics SarL |
Further Information
Publications
.
| Search: Chemistry Dep. / all Hamburg | |
| 2022 | |
| 157 |
Thermosensitive PLGA-PEG-PLGA Hydrogel as Depot Matrix for Allergen-Specific Immunotherapy Sonja Heine, Antonio Aguilar-Pimentel, Dennis Russkamp, Francesca Alessandrini, Valérie Gailus-Durner, Helmut Fuchs, Markus Ollert, Reinhard Bredehorst, Caspar Ohnmacht, Ulrich M. Zissler, Martin Hrabe de Angelis, Carsten B. Schmidt-Weber, Simon Blank Pharmaceutics 14, 1527 (16 pp) (2022) |
2019 | |
| 156 |
Induction of allergen-specific Tregs prior to oral or sublingual immunotherapy of food allergy Reinhard Bredehorst, Thomas Grunwald, Catherine Leonard, Markus W. Ollert -/- Applicant: Luxembourg Institure of Health, Tolerogenics S. A. R. L. Patent: WO 2019076477 (A1) 2019-04-25 |
| 155 |
Hydrogel-embedded oligodeoxynucleotides as tolerogenic adjuvant for subcutaneous immunotherapy Reinhard Bredehorst, Thomas Grunwald, Catherine Leonard, Markus W. Ollert , Bernhard Jungblut -/- Applicant: Luxembourg Institure of Health, Tolerogenics S. A. R. L. Patent: WO 2019076478 (A1) 2019-04-25 |
2017 | |
| 154 |
Matrix-embedded tolerance-promotion adjuvants for subcutaneous immunotherapy Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert Patent: EP 3251662 (A1) 2017-12-06 |
2016 | |
| 153 |
Antigen-specific immunotherapy using tolerizing liposomes Reinhard Bredehorst, Thomas Grunwald -/- Applicant: PLS-Design GmbH Patent: EP 3095440 (A1) 2016-11-23; US 2016338955 (A1) 2016-11-24 |
2015 | |
| 152 |
Induction of antigen-specific tolerance by peripheral phagocytosis Reinhard Bredehorst, Thomas Grunwald, Carsten Schmidt-Weber -/- Applicants: PLS-Design GmbH, Helmholtz Zentrum München Forschungszentrum für Gesundheit und Umwelt GmbH Patent: EP 2918262 (A1) 2015-09-16; US 2015283231 (A1) 2015-10-08 |
2014 | |
| 151 |
Identification of Hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens Liliana Cifuentes, Sebastian Vosseler, Simon Blank, Henning Seismann, Thomas Grunwald, Ulf Darsow, Reinhard Bredehorst, Martin Mempel, Edzard Spillner , Johannes Ring, Markus W. Ollert Journal of Allergy and Clinical Immunology 133, 909-910 (2014) |
| 150 |
Ausgründungen von Technologieunternehmen aus dem Fachbereich Chemie - Erfahrungen und Ausblicke Reinhard Bredehorst 400 Jahre Chemie als Wissenschaft in Hamburg. Von der Gründung des Akademischen Gymnasiums bis zu aktuellen Forschungsthemen am Fachbereich Chemie der Universität Hamburg 211-216 (2014), ISBN 978-3-86541-727-5 , Publisher: lehmanns media, Berlin |
| 149 |
Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber, Edzard Spillner -/- Applicants: PLS-Design GmbH, Klinikum rechts der Isar der TU München, Helmholtz Zentrum München Patent: EP 2746396 (A1) 2014-06-25 |
| 148 |
Low molecular weight immune-modulators as adjuvants for specific immunotherapy Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber -/- Applicants: PLS-Design GmbH, Klinikum rechts der Isar der technischen Universität München, Helmholtz Zentrum München Forschungszentrum für Gesundheit und Umwelt GmbH Patent: WO 2014198420 (A1) 2014-12-18; EP 2813242 (A1) 2014-12-17; US 2016271257 (A1) 2016-09-22 |
2013 | |
| 147 |
Controlled activation of complement components for use as endogenous adjuvant Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber, Edzard Spillner -/- Applicants: PLS-Design GmbH, Klinikum rechts der Isar der TU München, Helmholtz Zentrum München Patent: EP 2674167 (A1) 2013-12-18 |
| 146 |
Modulation of effector T cell responses by local depletion of complement component C3 Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber, Edzard Spillner -/- Applicants: PLS-Design GmbH, Klinikum rechts der Isar der TU München, Helmholtz Zentrum München Patent: EP 2674168 (A1) 2013-12-18 |
2011 | |
| 145 |
Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts Simon Blank, Henning Seismann, Yvonne Michel, Mareike McIntyre, Liliana Cifuentes, Ingke Braren, Thomas Grunwald, Ulf Darsow, Johannes Ring, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Allergy 66, 1322-1329 (2011) |
| 144 |
Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains Ingke Braren, Kerstin Greunke, Charles Pilette, Martin Mempel, Thomas Grunwald, Reinhard Bredehorst, Johannes Ring, Edzard Spillner , Markus W. Ollert Analytical Biochemistry 412, 134-140 (2011) |
| 143 |
Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the timothy grass major allergen Phl p 5a Julia Hecker, Andrea Diethers, Stefanie Etzold, Henning Seismann, Yvonne Michel, Melanie Plum, Reinhard Bredehorst, Simon Blank, Ingke Braren, Edzard Spillner Molecular Immunology 48, 1236-1244 (2011) |
| 142 |
Evaluation
of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells Simon Blank, Yvonne Michel, Henning Seismann, Melanie Plum, Kerstin Greunke, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Ingke Braren, Edzard Spillner Protein & Peptide Letters 18, 415-422 (2011) |
2010 | |
| 141 |
Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity Henning Seismann, Simon Blank, Liliana Cifuentes, Ingke Braren, Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Edzard Spillner Clinical and Molecular Allergy 8, 7-7 (2010) |
| 140 |
Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3 Simon Blank, Henning Seismann, Benjamin Bockisch, Ingke Braren, Liliana Cifuentes, Mareike McIntyre, Dana Rühl, Johannes Ring, Reinhard Bredehorst, Markus W. Ollert , Thomas Grunwald, Edzard Spillner Journal of Immunology 184, 5403-5413 (2010) |
| 139 |
Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of α-1,3-core fucosylation Henning Seismann, Simon Blank, Ingke Braren, Kerstin Greunke, Liliana Cifuentes, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Molecular Immunology 47, 799-808 (2010) |
2009 | |
| 138 |
Establishment of hapten-specific monoclonal avian IgY by conversion of antibody fragments obtained from combinatorial libraries Susanne Deckers, Ingke Braren, Kerstin Greunke, Nadine Meyer, Dana Rühl, Reinhard Bredehorst, Edzard Spillner Biotechnology and Applied Biochemistry 52, 79-87 (2009) |
| 137 |
Dissecting CCD reactivity in hymenoptera venom allergy by diminution of α-1,3-core fucosylation Simon Blank, Henning Seismann, Ingke Braren, Kerstin Greunke, Liliana Cifuentes, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Allergy 64 (Suppl. 90: Special Issue: Abstracts of the XXVIII EAACI Congress of the European Academy of Allergy and Clinical Immunology, Warszawa, Poland, 6-10 June 2009) 39-39 (79) (2009) |
| 136 |
Improvement of molecular diagnosis in hymenoptera venom hypersensitivity by the use of the recombinant major allergens Ves v 1 and Ves v 5 Henning Seismann, Simon Blank, Ingke Braren, Liliana Cifuentes, Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Edzard Spillner Allergy 64 (Suppl. 90: Special Issue: Abstracts of the XXVIII EAACI Congress of the European Academy of Allergy and Clinical Immunology, Warszawa, Poland, 6-10 June 2009) 39-39 (80) (2009) |
| 135 |
Chimeras of human IgE receptor a-chain and avian constant immunoglobulin domains for the determination of serum IgE Ingke Braren, Kerstin Greunke, Thomas Grunwald, Charles Pilette, Reinhard Bredehorst, Johannes Ring, Edzard Spillner , Markus W. Ollert Allergy 64 (Suppl. 90: Special Issue: Abstracts of the XXVIII EAACI Congress of the European Academy of Allergy and Clinical Immunology, Warszawa, Poland, 6-10 June 2009) 81-82 (174) (2009) |
| 134 |
Antibody compositions specific for IgE, IgG4 and IgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy Ingke Braren, Reinhard Bredehorst, Markus W. Ollert , Thomas Grunwald, Johannes Ring, Edzard Spillner Patent: EP 2022507 (A1) 2009-02-11 |
2008 | |
| 133 |
Recombinant IgY for improvement of immunoglobulin-based analytical applications Kerstin Greunke, Ingke Braren, Iris Alpers, Simon Blank, Jan Sodenkamp, Reinhard Bredehorst, Edzard Spillner Clinical Biochemistry 41, 1237-1244 (2008) |
| 132 |
Generation of a panel of monoclonal IgE antibodies with specificity for hymenoptera venom allergens Henning Seismann, Simon Blank, Ingke Braren, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 13-13 (29) (2008) |
| 131 |
Identification, recombinant expression and characterisation of high molecular weight hymenoptera venom allergens Simon Blank, Henning Seismann, Benjamin Bockisch, Ingke Braren, Reinhard Bredehorst, Markus W. Ollert , Thomas Grunwald, Edzard Spillner Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 13-13 (30) (2008) |
| 130 |
Addressing current challenges of allergy diagnostics using recombinant human antibody isotypes Ingke Braren, J. Heckerv, Simon Blank, Henning Seismann, Dana Rühl, Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Edzard Spillner Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 42-43 (90) (2008) |
2007 | |
| 129 |
Comparative expression of different antibody formats in mammalian cells and Pichia pastoris Ingke Braren, Kerstin Greunke, Oliver Umland, Susanne Deckers, Reinhard Bredehorst, Edzard Spillner Biotechnology and Applied Biochemistry 47, 205-214 (2007) |
| 128 |
Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant bacillus strain Lars Redecke , Maria A. Brehm, Reinhard Bredehorst Extremophiles 11, 75-83 (2007) |
| 127 |
Purification of native and recombinant Cobra Venom Factor using thiophilic adsorption chromatography Johanna Kölln, Ingke Braren, Reinhard Bredehorst, Edzard Spillner Protein & Peptide Letters 14, 475-480 (2007) |
| 126 |
Bivalent IgY antibody constructs for diagnostic and therapeutic applications Reinhard Bredehorst, Kerstin Greunke, Thomas Grunwald, Edzard Spillner Patent: EP 1757622 (A1) 2007-02-28 |
| 125 |
Chimeric proteins comprising human FcεRIα and avian IgY constant domain for detecting serum IgE and diagnosing allergy Ingke Braren, Reinhard Bredehorst, Thomas Grunwald -/- Applicant: PLS-Design GmbH Patent: EP 1777524 (A1) 2007-04-25 |
| 124 |
Method for determining an unknown PNA [peptide nucleic acid] sequence and uses thereof Reinhard Bredehorst, Jörn Glökler, Thomas Grunwald, Mark Matzas, Edzard Spillner Patent: EP 1785490 (A1) 2007-05-16 |
2006 | |
| 123 |
Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3) Thomas Grunwald, Benjamin Bockisch, Edzard Spillner , Johannes Ring, Reinhard Bredehorst, Markus W. Ollert Journal of Allergy and Clinical Immunology 117, 848-854 (2006) |
| 122 |
High level expression of monomeric and dimeric human α1,3-fucosyltransferase V Jan Münster, Patrick Ziegelmüller, Edzard Spillner , Reinhard Bredehorst Journal of Biotechnology 121, 448-457 (2006) |
| 121 |
Bivalent monoclonal IgY antibody formats by conversion of recombinant antibody fragments Kerstin Greunke, Edzard Spillner , Ingke Braren, Henning Seismann, Sabine Kainz, Ulrich Hahn , Thomas Grunwald, Reinhard Bredehorst Journal of Biotechnology 124, 446-456 (2006) |
| 120 |
Detection of TNT-analog TNP-TRIS in immunoassay with two recombinant scFv-antibodies Mladen Simonovic, B. R. Simonovic, S. Zlatanovic-Milosevic, Edzard Spillner , Reinhard Bredehorst Physical Chemistry 2006, Proceedings of the International Conference on Fundamental and Applied Aspects of Physical Chemistry, 8th, Belgrade, Serbia, Sept. 26-29, 2006, 1, 440-442 (2006) |
| 119 |
Inactivation of complement by recombinant human C3 derivatives Edzard Spillner , Johanna Kölln, Reinhard Bredehorst Advances in Experimental Medicine and Biology 586 (Current Topics in Complement) 347-360 (2006) |
2005 | |
| 118 |
Engineering of human complement component C3 for catalytic inhibition of complement Johanna Kölln, Reinhard Bredehorst, Edzard Spillner Immunology Letters 98, 49-56 (2005) |
| 117 |
Comparative Analysis of the Human and Chicken Prion Protein Copper Binding Regions at pH 6.5 Lars Redecke , Wolfram Meyer-Klaucke, Mirjam Koker, Joachim Clos, Dessislava Nikolova Georgieva, Nicolay Genov, Hartmut Echner, Hubert Kalbacher, Markus Perbandt , Reinhard Bredehorst, Wolfgang Voelter, Christian Betzel Journal of Biological Chemistry 280, 13987-13992 (2005) |
| 116 |
Immobilized stem-loop structured probes as conformational switches for enzymatic detection of microbial 16S rRNA Benjamin Bockisch, Thomas Grunwald, Edzard Spillner , Reinhard Bredehorst Nucleic Acids Research 33, e101/1-e101/8 (2005) |
| 115 |
Complement depletion using recombinant human C3-derivatives Johanna Kölln, Reinhard Bredehorst, Edzard Spillner Patent: WO 2005003159 (A1) 2005-01-13 |
2004 | |
| 114 |
Oligomerization of the proteolytic products is an intrinsic property of prion proteins Dessislava Nikolova Georgieva, Mirjam Koker, Lars Redecke , Markus Perbandt , Joachim Clos, Reinhard Bredehorst, Nicolay Genov, Christian Betzel Biochemical and Biophysical Research Communications 323, 1278-1286 (2004) |
| 113 |
Synthetic human prion protein octapeptide repeat binds to the proteinase K active site Dessislava Nikolova Georgieva, Wojciech Rypniewski, Hartmut Echner, Markus Perbandt , Mirjam Koker, Joachim Clos, Lars Redecke , Reinhard Bredehorst, Wolfgang Voelter, Nicolay Genov, Christian Betzel Biochemical and Biophysical Research Communications 325, 1406-1411 (2004) |
| 112 |
Complement Inactivation by Recombinant Human C3 Derivatives Johanna Kölln, Edzard Spillner , Jörg Andrä , Katrin Klensang, Reinhard Bredehorst Journal of Immunology 173, 5540-5545 (2004) |
| 111 |
Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells Johanna Kölln, Mark Matzas, Nathalie Janner, Thorsten Mix, Katrin Klensang, Reinhard Bredehorst, Edzard Spillner Molecular Immunology 41, 19-28 (2004) |
2003 | |
| 110 |
Paratope-based protein identification by antibody and peptide phage display Edzard Spillner , Susanne Deckers, Thomas Grunwald, Reinhard Bredehorst Analytical Biochemistry 321, 96-104 (2003) |
2002 | |
| 109 |
Key role of mitochondria in cerulenin-mediated apoptosis Sven Heiligtag, Reinhard Bredehorst, Kerstin A. David Cell Death and Differentiation 9, 1017-1025 (2002) |
| 108 |
System and method for detecting and quantifying nucleic acids using covalent binding Reinhard Bredehorst, Rainer Hintsche, Anton Heuberger Patent: WO 2002081738 (A2) 2002-10-17 |
| 107 |
Non-enzymatic liposome-linked closely spaced array electrodes assay (NEL-ELA) for detecting and quantifying nucleic acids Reinhard Bredehorst, Rainer Hintsche, Anton Heuberger Patent: WO 2002081739 (A2) 2002-10-17 |
| 106 |
Activated enzyme-linked detection systems for detecting and quantifying nucleic acids, antigens, antibodies and other analytes Reinhard Bredehorst, Rainer Hintsche, Anton Heuberger Patent: WO 2002082078 (A2) 2002-10-17 |
2001 | |
| 105 |
Structural studies on the cobra venom factor: isolation, purification, crystallization and preliminary crystallographic analysis Sujata Sharma, Talat Jabeen, Rajendra Kumar Singh, Reinhard Bredehorst, Carl-Wilhelm Vogel, Christian Betzel , Tej P. Singh Acta Crystallographica, Section D: Biological Crystallography D57, 596-598 (2001) |
| 104 |
A novel metastatic animal model reflecting the clinical appearance of human neuroblastoma: growth arrest of orthotopic tumors by natural, cytotoxic human immunoglobulin M antibodies Sylvia Engler, Christian Thiel, Kristine Förster, Kerstin A. David, Reinhard Bredehorst, Hartmut Juhl Cancer Research 61, 2968-2973 (2001) |
| 103 |
N-linked oligosaccharides of cobra venom factor contain novel α(1-3)galactosylated LeX structures D. Channe Gowda, John Glushka, Herman van Halbeek, Rao N. Thotakura, Reinhard Bredehorst, Carl-Wilhelm Vogel Glycobiology 11, 195-208 (2001) |
| 102 |
Preface Hans Steinhart, Angelika Paschke, Reinhard Bredehorst, S. Vieths Journal of Chromatography, B 756, 1-2 (2001) |
| 101 |
What establishes a protein as an allergen? Reinhard Bredehorst, Kerstin A. David Journal of Chromatography, B 756, 33-40 (2001) |
| 100 |
Initial
characterization of the apoptosis-inducing receptor for natural human anti-neuroblastoma IgM Kerstin A. David, Sven Heiligtag, Markus W. Ollert , M. Teppke, Carl-Wilhelm Vogel, Reinhard Bredehorst Medical and Pediatric Oncology 36, 251-257 (2001) |
2000 | |
| 99 |
Method for the production of planar microarrays of immobilized molecules by using microcompartments Reinhard Bredehorst, Reiner Hintsche, Rene Seitz, Walter Gumbrecht Patent: DE 19916867 (A1) 2000-10-19 |
| 98 |
Method for the preparation of electronic sensor arrays and their application as electrochemical transducers in DNA chips Jörg Albers, Helmut Bernt, Reinhard Bredehorst, Rainer Hintsche, Rene Seitz Patent: WO 2000062047 (A1) 2000-10-19 |
| 97 |
Sensor arrays with ultramicroelectrodes for biochemical affinity assays Jörg Albers, Helmut Bernt, Reinhard Bredehorst, Rainer Hintsche, Rene Seitz Patent: WO 2000062048 (A2) 2000-10-19 |
1999 | |
| 96 |
Human natural immunoglobulin M antibodies induce apoptosis of human neuroblastoma cells by binding to a Mr 260,000 antigen Kerstin A. David, Markus W. Ollert , Caren Vollmert, Sven Heiligtag, Britta Eickhoff, Rudolf Erttmann, Reinhard Bredehorst, Carl-Wilhelm Vogel Cancer Research 59, 3768-3775 (1999) |
| 95 |
Natural human IgM-antibodies in neuroblastoma therapy: preliminary findings of a phase I/II clinical trial Caroline Schmitt, Kerstin A. David, J. Hiller, J. Schrum, Reinhard Bredehorst, Carl-Wilhelm Vogel, C. Löliger, Rudolf Erttmann Klinische Pädiatrie 211, 314-318 (1999) |
| 94 |
Novel cobra venom factors and their use in lowering complement activity via recombinant proCVF Carl-Wilhelm Vogel, Reinhard Bredehorst, David C. Fritzinger, Michael A. Kock Patent: US 5922320 (A) 1999-07-13 |
| 93 |
In vivo binding pair pretargeting with antibodies and methotrexate analogs Nicholas Pomato, Richard P. McCabe, Gregory A. Hawkins, Reinhard Bredehorst, Chong-Ho Kim, Carl-Wilhelm Vogel Patent: US 5965106 (A) 1999-10-12 |
1998 | |
| 92 |
Dissociation rate kinetics in a solid-phase flow immunoassay Sina Y. Rabbany, Ronald T. Piervincenzi, Anne W. Kusterbeck, Reinhard Bredehorst, Frances S. Ligler Analytical Letters 31, 1663-1675 (1998) |
| 91 |
Protease-derivatized cobra venom factor with retention of bioactivity Markus W. Ollert , Patrick Ziegelmüller, Thomas Grunwald, Reinhard Bredehorst, Carl-Wilhelm Vogel Patent: US 5714344 (A) 1998-02-03 |
1997 | |
| 90 |
Assessment Of Heterogeneity in Antibody-Antigen Displacement Reactions Sina Y. Rabbany, Ronald T. Piervincenzi, Linda Judd, Anne W. Kusterbeck, Reinhard Bredehorst, Kristen Hakansson, Frances S. Ligler Analytical Chemistry 69, 175-182 (1997) |
| 89 |
Expression of a 260 kDa neuroblastoma surface antigen, the target of cytotoxic natural human IgM: correlation to MYCN amplification and effects of retinoic acid Kerstin A. David, A. Ehrhardt, Markus W. Ollert , Rudolf Erttmann, Reinhard Bredehorst, Carl-Wilhelm Vogel European Journal of Cancer 33, 1937-1941 (1997) |
| 88 |
Mechanisms of in vivo antineuroblastoma activity of human natural IgM Markus W. Ollert , Kerstin A. David, Caren Vollmert, Hartmut Juhl, Rudolf Erttmann, Reinhard Bredehorst, Carl-Wilhelm Vogel European Journal of Cancer 33, 1942-1948 (1997) |
| 87 |
Additive cytotoxicity of different monoclonal antibody-cobra venom factor conjugates for human neuroblastoma cells Hartmut Juhl, Eugene C. Petrella, Nai-Kong V. Cheung, Reinhard Bredehorst, Carl-Wilhelm Vogel Immunobiology 197, 444-459 (1997) |
| 86 |
Immunoconjugates Carl-Wilhelm Vogel, Reinhard Bredehorst -/- Editor: Renato Dulbecco Encyclopedia of Human Biology, 2nd Edition 4, 112.1-112.15 (1997), Publisher: Academic Press, San Diego |
1996 | |
| 85 |
Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans Kerstin A. David, Markus W. Ollert , Hartmut Juhl, Caren Vollmert, Rudolf Erttmann, Carl-Wilhelm Vogel, Reinhard Bredehorst Nature Medicine 2, 686-689 (1996) |
| 84 |
Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients Rudolf Erttmann, Caroline Schmitt, Markus W. Ollert , Kerstin A. David, Reinhard Bredehorst, Carl-Wilhelm Vogel Pediatric Hematology and Oncology 13, 545-548 (1996) |
| 83 |
Normal human serum contains a natural IgM antibody cytotoxic for human neuroblastoma cells Markus W. Ollert , Kerstin A. David, Caroline Schmitt, Alexander Hauenschild, Reinhard Bredehorst, Rudolf Erttmann, Carl-Wilhelm Vogel Proceedings of the National Academy of Sciences of the United States of America 93, 4498-4503 (1996) |
| 82 |
Structure and function of cobra venom factor, the complement-activating protein in cobra venom Carl-Wilhelm Vogel, Reinhard Bredehorst, David C. Fritzinger, Thomas Grunwald, Patrick Ziegelmüller, Michael A. Kock Advances in Experimental Medicine and Biology 391 (Natural Toxins 2) 97-114 (1996) |
| 81 |
In vivo binding pair pretargeting using targeting moiety-affinity component conjugate and affinity component binding partner-functional moiety conjugate Nicholas Pomato, Richard P. McCabe, Gregory A. Hawkins, Reinhard Bredehorst, Chong-Ho Kim, Carl-Wilhelm Vogel Patent: US 5578289 (A) 1996-11-26 |
| 80 |
High-yield manufacture of water-soluble dimeric to decameric chitin oligomers Reinhard Bredehorst, Nicholas Pomato, Oliver Scheel, Joachim Thiem -/- Applicants: AKZO Nobel NV, Reinhard Bredehorst, Nicholas Pomato, Oliver Scheel, Joachim Thiem Patent: WO 9626965 (A1) 1996-09-06 |
1995 | |
| 79 |
Cobra venom factor immunoconjugates: effects of carbohydrate-directed versus amino group-directed conjugation Jane J. Zara, Nicholas Pomato, Richard P. McCabe, Reinhard Bredehorst, Carl-Wilhelm Vogel Bioconjugate Chemistry 6, 367-372 (1995) |
| 78 |
Classical complement pathway activation on nucleated cells. Role of factor H in the control of deposited C3b Markus W. Ollert , Kerstin A. David, Reinhard Bredehorst, Carl-Wilhelm Vogel Journal of Immunology 155, 4955-4962 (1995) |
| 77 |
Molecular cloning and derived primary structure of cobra venom factor David C. Fritzinger, Reinhard Bredehorst, Carl-Wilhelm Vogel Proceedings of the National Academy of Sciences of the United States of America 92, 7605-7605 (1995) |
| 76 |
Binding kinetics of immobilized antibodies in a flow immunosensor Sina Y. Rabbany, Anne W. Kusterbeck, Reinhard Bredehorst, Frances S. Ligler Sensors and Actuators, B: Chemical B29, 72-78 (1995) |
| 75 |
Immunoconjugates in medicine (in Chinese) Reinhard Bredehorst, Carl-Wilhelm Vogel -/- Editor: Fuan Wang Internalization of Biological Macromolecules 223-236 (1995), Publisher: Science Press, Beijing |
| 74 |
Protease-derivatized cobra venom factor Markus W. Ollert , Patrick Ziegelmüller, Thomas Grunwald, Reinhard Bredehorst, Carl-Wilhelm Vogel Patent: WO 9507299 (A1) 1995-03-16 |
1994 | |
| 73 |
Effect of antibody density on the displacement kinetics of a flow immunoassay Sina Y. Rabbany, Anne W. Kusterbeck, Reinhard Bredehorst, Frances S. Ligler Journal of Immunological Methods 168, 227-234 (1994) |
| 72 |
Immunoreactivity and function of oligosaccharides in cobra venom factor D. Channe Gowda, Eugene C. Petrella, T. Tilak Raj, Reinhard Bredehorst, Carl-Wilhelm Vogel Journal of Immunology 152, 2977-2986 (1994) |
| 71 |
Antibody-mediated complement activation on nucleated cells Markus W. Ollert , Joseph V. Kadlec, Kerstin A. David, Eugene C. Petrella, Reinhard Bredehorst, Carl-Wilhelm Vogel Journal of Immunology 153, 2213-2221 (1994) |
| 70 |
Molecular cloning and derived primary structure of cobra venom factor David C. Fritzinger, Reinhard Bredehorst, Carl-Wilhelm Vogel Proceedings of the National Academy of Sciences of the United States of America 91, 12775-12779 (1994) |
| 69 |
Cobra venom factor, the complement-activating protein of cobra venom: Molecular cloning and derived primary structure David C. Fritzinger, Michael A. Kock, Thomas Grunwald, Patrick Ziegelmüller, B. Kunze, Markus W. Ollert , Reinhard Bredehorst, Carl-Wilhelm Vogel -/- Editor: Rainer Ansorge Hamburger Beiträge zur Wissenschaftsgeschichte 15, 565-591 (1994), ISBN 978-3-496-02540-5; 3-496-02540-9 , Publisher: Dietrich Reimer Verlag, Berlin - Hamburg Alternative Source Name: Schlaglichter der Forschung. Zum 75. Jahrestag der Universität Hamburg 1994 |
| 68 |
Molecular cloning of cDNA for cobra complement C3 and its analogs CVF1 and CVF2 David C. Fritzinger, Reinhard Bredehorst, Carl-Wilhelm Vogel Patent: WO 9423024 (A1) 1994-10-13 |
1993 | |
| 67 |
Continuous-flow immunosensor for detection of explosives James P. Whelan, Anne W. Kusterbeck, Gregory A. Wemhoff, Reinhard Bredehorst, Frances S. Ligler Analytical Chemistry 65, 3561-3565 (1993) |
| 66 |
Molecular basis of complement resistance of human melanoma cells expressing the C3-cleaving membrane protease p65 Markus W. Ollert , Joseph V. Kadlec, Eugene C. Petrella, Reinhard Bredehorst, Carl-Wilhelm Vogel Cancer Research 53, 592-599 (1993) |
| 65 |
Delivery of radionuclides to pretargeted monoclonal antibodies using dihydrofolate reductase and methotrexate in an affinity system Gregory A. Hawkins, Richard P. McCabe, Chong-Ho Kim, Ramaswamy Subramanian, Reinhard Bredehorst, Gregory A. McCullers, Carl-Wilhelm Vogel, Michael G. Hanna, Nicholas Pomato Cancer Research 53, 2368-2373 (1993) |
1992 | |
| 64 |
Kinetics of antibody binding at solid-liquid interfaces in flow Gregory A. Wemhoff, Sina Y. Rabbany, Anne W. Kusterbeck, Robert A. Ogert, Reinhard Bredehorst, Frances S. Ligler Journal of Immunological Methods 156, 223-230 (1992) |
| 63 |
Primary structure of cobra complement component C3 David C. Fritzinger, Eugene C. Petrella, Mark B. Connelly, Reinhard Bredehorst, Carl-Wilhelm Vogel Journal of Immunology 149, 3554-3562 (1992) |
| 62 |
Structure of the major oligosaccharide of cobra venom factor D. Channe Gowda, Michael Schultz, Reinhard Bredehorst, Carl-Wilhelm Vogel Molecular Immunology 29, 335-342 (1992) |
| 61 |
Continuous flow immunoassay: use of a novel trifunctional carrier molecule for the synthesis of fluorophore-labeled antigens Reinhard Bredehorst, Gregory A. Wemhoff, Anne W. Kusterbeck, Paul T. Charles, Frances S. Ligler, Carl-Wilhelm Vogel GBF Monographs 17 (Fundamentals, Technologies and Applications) 453-460 (1992) |
1991 | |
| 60 |
Novel trifunctional carrier molecule for the fluorescent labeling of haptens Reinhard Bredehorst, Gregory A. Wemhoff, Anne W. Kusterbeck, Paul T. Charles, Richard B. Thompson, Frances S. Ligler, Carl-Wilhelm Vogel Analytical Biochemistry 193, 272-279 (1991) |
| 59 |
A
carbohydrate-directed heterobifunctional cross-linking reagent for the synthesis of immunoconjugates Jane J. Zara, Richard D. Wood, Peter Boon, Chong-Ho Kim, Nicholas Pomato, Reinhard Bredehorst, Carl-Wilhelm Vogel Analytical Biochemistry 194, 156-162 (1991) |
| 58 |
Immobilization of active agents on hydroxyl group-carrying substrates with a silane and heterobifunctional crosslinking agent Frances S. Eigler, Jacque Georger, Suresh K. Bhatia, Jeff Calvert, Lisa C. Shriver-Lake, Reinhard Bredehorst Patent: US 5077210 (A) 1991-12-31 |
| 57 |
Ligand-label conjugates which contain polyoxoanions of sulfur or phosphorus Reinhard Bredehorst, Frances S. Ligler, Anne W. Kusterbeck, Gregory A. Wemhoff, Carl-Wilhelm Vogel Patent: WO 9116344 (A1) 1991-10-31 |
1990 | |
| 56 |
A continuous flow immunoassay for rapid and sensitive detection of small molecules Anne W. Kusterbeck, Gregory A. Wemhoff, Paul T. Charles, Doyle A. Yeager, Reinhard Bredehorst, Carl-Wilhelm Vogel, Frances S. Ligler Journal of Immunological Methods 135, 191-197 (1990) |
| 55 |
C3-cleaving membrane proteinase. A new complement regulatory protein of human melanoma cells Markus W. Ollert , Raymond Frade, Anny Fiandino, Mounanandham Panneerselvam, Eugene C. Petrella, Monique Barel, Michael K. Pangburn, Reinhard Bredehorst, Carl-Wilhelm Vogel Journal of Immunology 144, 3862-3867 (1990) |
| 54 |
Complement killing of human neuroblastoma cells: a cytotoxic monoclonal antibody and its F(ab)'2-cobra venom factor conjugate are equally cytotoxic Hartmut Juhl, Eugene C. Petrella, Nai-Kong V. Cheung, Reinhard Bredehorst, Carl-Wilhelm Vogel Molecular Immunology 27, 957-964 (1990) |
| 53 |
Spezifische Elimination humaner Neuroblastomzellen durch die Anwendung von monoklonalen Antikörper-Cobra Venom Faktor Conjugaten: Ein Modell zur Tumor-Therapie (Specific elimination of human Neuroblastoma cells by monoclonal antibody-cobra venom factor conjugates: a tumor therapy model) Hartmut Juhl, Eugene C. Petrella, Nai-Kong V. Cheung, Reinhard Bredehorst, Carl-Wilhelm Vogel -/- Editors: Rudolf Häring, Konrad Meßmer, Edgar Ungeheuer Chirurgisches Forum '90 für experimentelle und klinische Forschung 289-295 (1990), ISBN 978-3-540-52392-5 , Publisher: Springer-Verlag, Berlin, Heidelberg Alternative Source Name: 107. Kongreß der Deutschen Gesellschaft für Chirurgie, Berlin, 17.-21. April 1990; Langenbecks Archiv fur Chirurgie vereinigt mit Bruns' Beiträge fur Klinische Chirurgie, Supplement 1990 |
| 52 |
The central role of cell surface-deposited C3b for the Complement susceptibility of human melanoma cells Reinhard Bredehorst, Carl-Wilhelm Vogel -/- Editor: Soldano Ferrone Human Melanoma. Immunology, Diagnostics and Therapy 133-150 (1990), Publisher: Springer-Verlag, Berlin, Heidelberg |
| 51 |
Site-specific in-vivo activation of prodrugs Reinhard Bredehorst, Chong-Ho Kim, Richard P. McCabe, Nicholas Pomato, Carl-Wilhelm Vogel Patent: WO 9007929 (A1) 1990-07-26 |
| 50 |
Preparation of site-specific heterobifunctional crosslinking reagents, their use, and kits containing them Jane J. Zara, Richard D. Wood, Reinhard Bredehorst, Carl-Wilhelm Vogel Patent: WO 9010621 (A1) 1990-09-20 |
1989 | |
| 49 |
Use of thiol-terminal silanes and heterobifunctional crosslinkers for immobilization of antibodies on silica surfaces Suresh K. Bhatia, Lisa C. Shriver-Lake, Kimberly J. Prior, Jacque H. Georger, Jeffrey M. Calvert, Reinhard Bredehorst, Frances S. Ligler Analytical Biochemistry 178, 408-413 (1989) |
1988 | |
| 48 |
Quantitation of coronary venous adenosine in patients: limitations evaluated by radioimmunoassay Christian W. Hamm, Ernst-Wolfram Kupper, Reinhard Bredehorst, Helmuth Hilz, Walter Bleifeld Cardiovascular Research 22, 236-243 (1988) |
| 47 |
Liposome-based immunoassays for detection of small and large molecules Bruce P. Gaber, Frances S. Ligler, Reinhard Bredehorst -/- Editor: Bruce P. Gaber, J. M. Schnur, D. Chapman Advances in Experimental Medicine and Biology 238 (Biotechnological Applications of Lipid Microstructures) 209-214 (1988) |
| 46 |
Potential use of monoclonal antibody-drug conjugates to prevent drug resistance Carl-Wilhelm Vogel, Reinhard Bredehorst, Mounanandham Panneerselvam, Carole J. Spangler -/- Editor: P. V. Woolley, K. P. Tew Bristol-Myers Cancer Symposia 9 (Mechanisms of Drug Resistance in Neoplastic Cells) 371-383 (1988), Publisher: Academic Press, New York |
| 45 |
Detectably labeled cephalosporin assay for β-lactamase determination Reinhard Bredehorst, Abdolhossen Talebian, Charles F. Hammer, Carl-Wilhelm Vogel Patent: US 4764462 (A) 1988-08-16 |
1987 | |
| 44 |
A homogeneous immunoassay for the mycotoxin T-2 utilizing liposomes, monoclonal antibodies, and complement Frances S. Ligler, Reinhard Bredehorst, Abdolhossen Talebian, Lisa C. Shriver, Charles F. Hammer, James P. Sheridan, Carl-Wilhelm Vogel, Bruce P. Gaber Analytical Biochemistry 163, 369-375 (1987) |
| 43 |
Resistance of human melanoma cells against the cytotoxic and complement-enhancing activities of doxorubicin Mounanandham Panneerselvam, Reinhard Bredehorst, Carl-Wilhelm Vogel Cancer Research 47, 4601-4607 (1987) |
| 42 |
Doxorubicin enhances complement susceptibility of human melanoma cells by extracellular oxygen radical formation Reinhard Bredehorst, Mounanandham Panneerselvam, Carl-Wilhelm Vogel Journal of Biological Chemistry 262, 2034-2041 (1987) |
| 41 |
Radioimmunoassay of oxidized and reduced pyridine nucleotides Reinhard Bredehorst, Helmuth Hilz -/- Editor: D. Dolphin, R. Poulson, O. Avramovic Coenzymes and Cofactors 2B (Pyridine Nucleotide Coenzymes: Chemical, Biochemical, and Medical Aspects) 189-201 (1987), Publisher: John Wiley & Sons, Inc., New York, London, Sydney, Toronto |
1986 | |
| 40 |
Effect of covalent attachment of immunoglobulin fragments on liposomal integrity Reinhard Bredehorst, Frances S. Ligler, Anne W. Kusterbeck, Eddie L. Chang, Bruce P. Gaber, Carl-Wilhelm Vogel Biochemistry 25, 5693-5698 (1986) |
| 39 |
Immobilized doxorubicin increases the complement susceptibility of human melanoma cells by protecting complement component C3b against inactivation Mounanandham Panneerselvam, Reinhard Bredehorst, Carl-Wilhelm Vogel Proceedings of the National Academy of Sciences of the United States of America 83, 9144-9148 (1986) |
1985 | |
| 38 |
Quantitation of hepatitis B virus (HBV) core antigen in serum in the presence of antibodies to HBV core antigen: comparison with assays of serum HBV DNA, DNA polymerase, and HBV e antigen Reinhard Bredehorst, Hinrik von Wulffen, Celso Granato Journal of Clinical Microbiology 21, 593-598 (1985) |
1984 | |
| 37 |
Quantification of protein-bound ADP-ribosyl and (ADP-ribosyl)n residues Klaus Wielckens, Reinhard Bredehorst, Helmuth Hilz Methods in Enzymology 106 (Posttranslational Modifications Part A) 472-482 (1984) |
1983 | |
| 36 |
Quantification without purification of blood and tissue adenosine by radioimmunoassay Reinhard Bredehorst, Klaus Wielckens, Ernst-Wolfram Kupper, Werner Schnabel, Helmuth Hilz Analytical Biochemistry 135, 156-164 (1983) |
| 35 |
Ergebnisse einer aktiven Schutzimpfung gegen die Hepatitis B mit deutschem Impfstoff (Results of active preventive vaccination against hepatitis B with a German vaccine) H. Henning, Rainer Laufs, Karin Kätzner, Reinhard Bredehorst Zeitschrift für Gastroenterologie 21, 111-114 (1983) |
| 34 |
Mono ADP-Ribosylierung: ein neuer Typus der postsynthetischen Modifikation von Proteinen Reinhard Bredehorst Habilitationsschrift, Hamburg (1983) |
| 33 |
Functional aspects of mono- and poly(ADP-ribosyl)ation: subcellular distribution and ADP-ribosyl turnover under conditions of repair and 'starvation' Helmuth Hilz, Klaus Wielckens, Peter Adamietz, Reinhard Bredehorst, A. Kreymeier -/- Editor: Masanao Miwa, Osamu Hayaishi, Sydney Shall, Mark Smulson, Takashi Sugimura ADP-Ribosylation, DNA Repair and Cancer: Proceedings of the 13th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1982, 155-163 (1983), Publisher: Japan Sci. Soc. Press, Tokyo; VNU Science Press,Utrecht |
| 32 |
ADP-ribosylation of proteins in normal and neoplastic tissues Helmuth Hilz, Peter Adamietz, Reinhard Bredehorst, Klaus Wielckens -/- Editor: Prakash Chandra NATO ASI Series, Series A: Life Sciences 57 (Biochemical and Biological Markers of Neoplastic Transformation) 251-262 (1983) |
1982 | |
| 31 |
Mono ADP-ribosylation and poly ADP-ribosylation of proteins in normal and malignant tissues Klaus Wielckens, Reinhard Bredehorst, Peter Adamietz, Helmuth Hilz Advances in Enzyme Regulation 20, 23-37 (1982) |
| 30 |
DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins Klaus Wielckens, Albrecht Schmidt, Edda George, Reinhard Bredehorst, Helmuth Hilz Journal of Biological Chemistry 257, 12872-12877 (1982) |
| 29 |
Subfractions and subcellular distribution of mono(ADP-ribosyl) proteins in eukaryotic cells Helmuth Hilz, Reinhard Bredehorst, Peter Adamietz, Klaus Wielckens -/- Editor: Osamu Hayaishi, Kunihiro Ueda ADP-Ribosylation Reactions 207-219 (1982) |
| 28 |
Quantitation of mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins Helmuth Hilz, Klaus Wielckens, Reinhard Bredehorst -/- Editor: Osamu Hayaishi, Kunihiro Ueda ADP-Ribosylation Reactions 305-321 (1982) |
1981 | |
| 27 |
A chemical procedure for the specific conversion of poly(adenosine diphosphate ribose) to phosphoribosyl-AMP Peter Adamietz, Reinhard Bredehorst Analytical Biochemistry 112, 314-322 (1981) |
| 26 |
Subcellular distribution of mono(ADP-ribose) protein conjugates in rat liver Peter Adamietz, Klaus Wielckens, Reinhard Bredehorst, H. Lengyel, Helmuth Hilz Biochemical and Biophysical Research Communications 101, 96-103 (1981) |
| 25 |
Mono- and poly-ADP-ribosylation of proteins in mouse kidney after castration and testosterone treatment Axel Gartemann, Reinhard Bredehorst, Klaus Wielckens, Wolf H. Strätling, Helmuth Hilz Biochemical Journal 198, 37-44 (1981) |
| 24 |
Determination of 5'-AMP in the presence of excess 3'(2')-AMP with the aid of antibodies raised against N6-carboxymethyl-5'-AMP conjugates. Use for the quantitation of pyridine nucleotides and of protein-bound ADP-ribose Reinhard Bredehorst, Mila Maria Schlueter, Helmuth Hilz Biochimica et Biophysica Acta, Nucleic Acids and Protein Synthesis 652, 16-28 (1981) |
| 23 |
Protein-bound polymeric and monomeric ADP-ribose residues in hepatic tissues. Comparative analyses using a new procedure for the quantification of poly(ADP-ribose) Klaus Wielckens, Reinhard Bredehorst, Peter Adamietz, Helmuth Hilz European Journal of Biochemistry 117, 69-74 (1981) |
| 22 |
Mono(ADP-ribosyl)ation and poly(ADP-ribosyl)ation of proteins in developing liver and in hepatomas. Relation of conjugate subfractions to metabolic competence and proliferation rates Reinhard Bredehorst, Klaus Wielckens, Peter Adamietz, Elisabeth Steinhagen-Thiessen, Helmuth Hilz European Journal of Biochemistry 120, 267-274 (1981) |
| 21 |
Mono ADP-ribosylation and poly ADP-ribosylation of proteins Helmuth Hilz, Peter Adamietz, Reinhard Bredehorst, Klaus Wielckens -/- Editor: Helmut Holzer Metabolic Interconversion of Enzymes, 1980: International Titisee Conference, October 1st-5th, 1980 (Proceedings in Life Sciences) 269-279 (1981), Publisher: Springer-Verlag, Berlin, Heidelberg, New York |
1980 | |
| 20 |
Protein-bound mono(ADP-ribose) residues in differentiating cells of Dictyostelium discoideum Reinhard Bredehorst, Karin Klapproth, Helmuth Hilz, Conrad Scheidegger, Günther Gerisch Cell Differentiation 9, 95-103 (1980) |
| 19 |
Increase of mono(ADP-ribose) protein conjugate levels in rat liver induced by nicotinamide administration Reinhard Bredehorst, Helgard Lengyel, Helmuth Hilz, Doris Stärk, Günther Siebert Hoppe-Seyler's Zeitschrift für Physiologische Chemie 361, 559-562 (1980) |
| 18 |
Covalent modification of nuclear proteins by ADP-ribosylation: marked differences in normal and tumor tissues Helmuth Hilz, Peter Adamietz, Reinhard Bredehorst, Klaus Wielckens Biol. Cancer Cell, Proc. Meet. Eur. Assoc. Cancer Res. (E.A.C.R.), 5th 409-414 (1980), Publisher: Kugler Publications, Amsterdam |
| 17 |
Quantitation
of mono(ADPR) protein conjugates from intact tissues at various stages of gene expression Helmuth Hilz, Reinhard Bredehorst, Klaus Wielckens, Peter Adamietz -/- Editor: Mark E. Smulson, Takashi Sugimura Developments in Cell Biology (Amsterdam) 6, 143-152 (1980), Publisher: Elsevier North Holland, New York Alternative Source Name: Proceedings of the Fogarty International Conference on Novel ADP-Ribosylations of Regulatory Enzymes and Proteins, National Institutes of Health, Bethesda, Maryland, U.S.A., October 22-24, 1979 |
1979 | |
| 16 |
ADP-ribosylation of nuclear proteins Helmuth Hilz, Peter Adamietz, Reinhard Bredehorst, Klaus Wielckens Advances in Enzyme Regulation 17, 195-211 (1979) |
| 15 |
Determination of radioimmunoassay of the sum of oxidized and reduced forms of NAD and NADP in picomole quantities from the same acid extract Reinhard Bredehorst, Helgard Lengyel, Helmuth Hilz European Journal of Biochemistry 99, 401-411 (1979) |
| 14 |
Intrinsic ADP-ribose transferase activity versus levels of mono(ADP-ribose) protein conjugates in proliferating Ehrlich ascites tumor cells Reinhard Bredehorst, Markus Goebel, Fatma Renzi, Margrid Kittler, Karin Klapproth, Helmuth Hilz Hoppe-Seyler's Zeitschrift für Physiologische Chemie 360, 1737-1743 (1979) |
1978 | |
| 13 |
Rapid determination of chain length pattern in poly(ADP-ribose) samples Peter Adamietz, Reinhard Bredehorst, Helmuth Hilz Biochemical and Biophysical Research Communications 81, 1377-1383 (1978) |
| 12 |
Production of antibodies against ADP-ribose and 5'-AMP with the aid of N6-carboxymethylated ADP-ribose conjugates Reinhard Bredehorst, Ari M. Ferro, Helmuth Hilz European Journal of Biochemistry 82, 105-113 (1978) |
| 11 |
Determination of ADP-ribose and poly(ADP-ribose) by a new radioimmunoassay Reinhard Bredehorst, Ari M. Ferro, Helmuth Hilz European Journal of Biochemistry 82, 115-121 (1978) |
| 10 |
ADP-ribosylated histone H1 from HeLa cultures. Fundamental differences to (ADP-ribose)n-histone H1 conjugates formed in vitro Peter Adamietz, Reinhard Bredehorst, Helmuth Hilz European Journal of Biochemistry 91, 317-326 (1978) |
| 9 |
Two different types of bonds linking single ADP-ribose residues covalently to proteins. Quantification in eukaryotic cells Reinhard Bredehorst, Klaus Wielckens, Axel Gartemann, Helgard Lengyel, Karin Klapproth, Helmuth Hilz European Journal of Biochemistry 92, 129-135 (1978) |
| 8 |
Entwicklung einer Isotopenverdünnungsmethode zur Bestimmung von poly(Adenosindiphosphat-Ribose)-Spiegeln in intakten Geweben Reinhard Bredehorst -/- Supervisor: Helmuth Hilz Dissertation, Hamburg (1978) |
| 7 |
ADP-ribosylation of nuclear proteins Helmuth Hilz, Peter Adamietz, Peter R. Stone, Reinhard Bredehorst, C. Philipps -/- Editor: P. W. Kent New Approaches to Genetics. Developments in Molecular Genetics 126-139 (1978), Publisher: Oriel Press, Stocksfield, London, Henley on Thames, Boston |
1976 | |
| 6 |
Quantitative determination of poly(adenosine diphosphate ribose in different hepatic tissues by an isotope dilution procedure Peter R. Stone, Reinhard Bredehorst, Margrit Kittler, Helgard Lengyel, Helmuth Hilz Hoppe-Seyler's Zeitschrift für Physiologische Chemie 357, 51-56 (1976) |
| 5 |
Poly(ADP-ribose) and cell proliferation Helmuth Hilz, Peter Adamietz, Reinhard Bredehorst, A. Ferro, Uwe Leiber, Margrit Kittler, J. Preiss, Peter R. Stone Forschungsbericht. Bundesministerium für Forschung und Technologie BMFT-FB-T-76-36 (Experimentelle Studien zur Chemotherapie des Krebses) 157-166 (1976) |
1975 | |
| 4 |
Proceedings: Quantitative determination of poly(ADP-ribose) in mammalian tissues Peter R. Stone, Reinhard Bredehorst, Margrid Kittler, Ari Ferro, Helmuth Hilz Journal of Biochemistry 77 (Supplement 1) 6-6 (1975) |
1974 | |
| 3 |
Nuclear poly (ADPR) [ADP-ribose] and mono (ADPR) [ADP-ribose] residues in tissues with different growth rates Peter Adamietz, Reinhard Bredehorst, M. Oldekop, Helmuth Hilz FEBS Letters 43, 318-322 (1974) |
| 2 |
Proceedings: Quantitative determination of poly(ADP-ribose) in mammalian cells Peter R. Stone, Reinhard Bredehorst, Margrit Kittler, Helmuth Hilz Hoppe-Seyler's Zeitschrift für Physiologische Chemie 355, 1259-1260 (1974) |
| 1 |
Enzymes of poly(ADP-ribose) metabolism and the possible function of the polymer Helmuth Hilz, Peter Adamietz, Reinhard Bredehorst, Uwe Leiber -/- Editor: Maureen Harris Poly (ADP-ribose) : an international symposium, National Institutes of Health, Bethesda, Maryland, June 11-13, 1973, 47-67 (1974), Publisher: DHEW Publication, (NIH), Washington |