Fachbereich Chemie
Publikationen von Edzard Spillner
Weitere Informationen
Publikationen
(nur bis zum Ende der Hamburger Zeit, bis 2014)
.
| Suche: FB Chemie / Hamburg | |
| 2014 | |
| 66 |
Identification
of Hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens Liliana Cifuentes, Sebastian Vosseler, Simon Blank, Henning Seismann, Thomas Grunwald, Ulf Darsow, Reinhard Bredehorst, Martin Mempel, Edzard Spillner , Johannes Ring, Markus W. Ollert Journal of Allergy and Clinical Immunology 133, 909-910 (2014) |
| 65 |
Component resolution reveals additional major allergens in patients with honeybee venom allergy Julian Köhler, Simon Blank, Sabine Müller, Frank I. Bantleon, Marcel Frick, Johannes Huss-Marp, Jonas Lidholm, Edzard Spillner , Thilo Jakob Journal of Allergy and Clinical Immunology 133, 1383-1389 (2014) |
| 64 |
Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients Josef Singer, Judit Fazekas, Wei Wang, Marlene Weichselbaumer, Miroslawa Matz, Alexander Mader, Willibald Steinfellner, Sarah Meitz, Diana Mechtcheriakova, Yuri Sobanov, Michael Willmann, Thomas Stockner, Edzard Spillner , Renate Kunert, Erika Jensen-Jarolim Molecular Cancer Therapeutics 13, 1777-1790 (2014) |
| 63 |
Selective local inhibition of TNFR1-mediated functions at the site of antigen/allergen presentation Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber, Edzard Spillner -/- Anmelder: PLS-Design GmbH, Klinikum rechts der Isar der TU München, Helmholtz Zentrum München Patent: EP 2746396 (A1) 2014-06-25 |
2013 | |
| 62 |
Donor Assists Acceptor Binding and Catalysis of Human α1,6-Fucosyltransferase Miriam P. Koetzler, Simon Blank, Frank I. Bantleon, Martin Wienke, Edzard Spillner , Bernd Meyer ACS Chemical Biology 8, 1830-1840 (2013) |
| 61 |
Extending the honeybee venome with the antimicrobial peptide apidaecin and a protein resembling wasp antigen 5 Matthias van Vaerenbergh, Dries Cardoen, Ellen M. Formesyn, Marleen Brunain, Gonzalez van Driessche, Simon Blank, Edzard Spillner , Peter Verleyen, Tom Wenseleers, Liliane Schoofs, Bart Devreese, Dirk C. de Graaf Insect Molecular Biology 22, 199-210 (2013) |
| 60 |
Polistes species venom is devoid of carbohydrate-based cross-reactivity and allows interference-free diagnostics Simon Blank, Charles Neu, Daniel Hasche, Frank I. Bantleon, Thilo Jakob, Edzard Spillner Journal of Allergy and Clinical Immunology 131, 1239-1242 (2013) |
| 59 |
Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris venom Simon Blank, Henning Seismann, Mareike McIntyre, Markus W. Ollert , Sara V. Wolf, Frank I. Bantleon, Edzard Spillner PLoS One 8, e62009 (2013) |
| 58 |
Controlled activation of complement components for use as endogenous adjuvant Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber, Edzard Spillner -/- Anmelder: PLS-Design GmbH, Klinikum rechts der Isar der TU München, Helmholtz Zentrum München Patent: EP 2674167 (A1) 2013-12-18 |
| 57 |
Modulation of effector T cell responses by local depletion of complement component C3 Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Carsten Schmidt-Weber, Edzard Spillner -/- Anmelder: PLS-Design GmbH, Klinikum rechts der Isar der TU München, Helmholtz Zentrum München Patent: EP 2674168 (A1) 2013-12-18 |
2012 | |
| 56 |
Potential, Fallstricke und aktueller Status der molekularen Allergie-Diagnostik am Beispiel der Insektengift-Allergie Edzard Spillner , Simon Blank, Thilo Jakob Allergo Journal 249-258 (2012) |
| 55 |
An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE Julia Hecker, Daniela Schulz, Andrea Diethers, Melanie Plum, Martin Mempel, Markus W. Ollert , Thilo Jakob, Simon Blank, Ingke Braren, Edzard Spillner Allergy 67, 1530-1537 (2012) |
| 54 |
Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8) Miriam P. Koetzler, Simon Blank, Frank I. Bantleon, Edzard Spillner , Bernd Meyer Biochimica et Biophysica Acta, General Subjects 1820, 1915-1925 (2012) |
| 53 |
Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy Edzard Spillner , Ingke Braren, Kerstin Greunke, Henning Seismann, Simon Blank, Dion du Plessis Biologicals 40, 313-322 (2012) |
| 52 |
Recombinant IgE Antibody engineering to target EGFR Edzard Spillner , Melanie Plum, Simon Blank, Michaela Miehe, Ingke Braren Cancer Immunology, Immunotherapy 61, 1565-1573 (2012) |
| 51 |
The major royal jelly proteins 8 and 9 are glycosylated components of Apis mellifera venom with reduced allergenic potential beyond carbohydrate based reactivity Simon Blank, Frank I. Bantleon, Mareike McIntyre, Markus W. Ollert , Edzard Spillner Clinical and Experimental Allergy 42, 976-985 (2012) |
| 50 |
Formation of the immunogenic α1,3-fucose epitope: Elucidation of substrate specificity and of enzyme mechanism of core fucosyltransferase A Miriam P. Koetzler, Simon Blank, Henning N. Behnken, Dirk Alpers, Frank I. Bantleon, Edzard Spillner , Bernd Meyer Insect Biochemistry and Molecular Biology 42, 116-125 (2012) |
| 49 |
Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model Claudia Wehr, Fabian Müller, Julia Schüler, Tina Tomann, Claudia Nitschke, Henning Seismann, Edzard Spillner , Kerstin Klingner, Tanja Schneider-Merck, Mascha Binder, Heinz-Herbert Fiebig, Roland Mertelsmann, Martin Trepel International Journal of Cancer 131, E10-E20 (2012) |
| 48 |
Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy Thilo Jakob, Julian Köhler, Simon Blank, Ulrika Magnusson, Johannes Huss-Marp, Edzard Spillner , Jonas Lidholm Journal of Allergy and Clinical Immunology 130, 276-278 (2012) |
| 47 |
The Putative Serine Protease Inhibitor Api m 6 From Apis mellifera Venom: Recombinant and Structural Evaluation Yvonne Michel, Mareike McIntyre, Helene Ginglinger, Markus W. Ollert , Liliana Cifuentes, Simon Blank, Edzard Spillner Journal of Investigational Allergology and Clinical Immunology 22, 476-484 (2012) |
2011 | |
| 46 |
Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts Simon Blank, Henning Seismann, Yvonne Michel, Mareike McIntyre, Liliana Cifuentes, Ingke Braren, Thomas Grunwald, Ulf Darsow, Johannes Ring, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Allergy 66, 1322-1329 (2011) |
| 45 |
Quantitation of serum IgE by using chimeras of human IgE receptor and avian immunoglobulin domains Ingke Braren, Kerstin Greunke, Charles Pilette, Martin Mempel, Thomas Grunwald, Reinhard Bredehorst, Johannes Ring, Edzard Spillner , Markus W. Ollert Analytical Biochemistry 412, 134-140 (2011) |
| 44 |
Rekombinante Insektengiftallergene: Ist das Wespen- oder doch das Bienengift schuld? Thilo Jakob, Markus W. Ollert , Edzard Spillner , Simon Blank Der Deutsche Dermatologe 59, 759-761 (2011) |
| 43 |
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex Nick S. Laursen, Kasper R. Andersen, Ingke Braren, Edzard Spillner , Lars Sottrup-Jensen, Gregers R. Andersen EMBO Journal 30, 606-616 (2011) |
| 42 |
Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy Gunter J. Sturm, Wolfgang Hemmer, Thomas Hawranek, Roland Lang, Markus W. Ollert , Edzard Spillner , Simon Blank, Danijela Bokanovic, Werner Aberer Journal of Allergy and Clinical Immunology 128, 247-248 (2011) |
| 41 |
Close-up of the α-1,3-Gal epitope as defined by a monoclonal chimeric IgE and human serum using saturation transfer difference (STD) NMR Melanie Plum, Yvonne Michel, Katharina Wallach, Tim Raiber, Simon Blank, Frank I. Bantleon, Andrea Diethers, Kerstin Greunke, Ingke Braren, Thomas Hackl , Bernd Meyer , Edzard Spillner Journal of Biological Chemistry 286, 43103-43111 (2011) |
| 40 |
Generation and epitope analysis of human monoclonal antibody isotypes with specificity for the timothy grass major allergen Phl p 5a Julia Hecker, Andrea Diethers, Stefanie Etzold, Henning Seismann, Yvonne Michel, Melanie Plum, Reinhard Bredehorst, Simon Blank, Ingke Braren, Edzard Spillner Molecular Immunology 48, 1236-1244 (2011) |
| 39 |
Evaluation of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells Simon Blank, Yvonne Michel, Henning Seismann, Melanie Plum, Kerstin Greunke, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Ingke Braren, Edzard Spillner Protein & Peptide Letters 18, 415-422 (2011) |
2010 | |
| 38 |
Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivity Henning Seismann, Simon Blank, Liliana Cifuentes, Ingke Braren, Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Edzard Spillner Clinical and Molecular Allergy 8, 7-7 (2010) |
| 37 |
Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3 Simon Blank, Henning Seismann, Benjamin Bockisch, Ingke Braren, Liliana Cifuentes, Mareike McIntyre, Dana Rühl, Johannes Ring, Reinhard Bredehorst, Markus W. Ollert , Thomas Grunwald, Edzard Spillner Journal of Immunology 184, 5403-5413 (2010) |
| 36 |
Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of α-1,3-core fucosylation Henning Seismann, Simon Blank, Ingke Braren, Kerstin Greunke, Liliana Cifuentes, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Molecular Immunology 47, 799-808 (2010) |
| 35 |
Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells Mascha Binder, Barbara Lechenne, Ramesh Ummanni, Christan Scharf, Stefan Balabanov, Maria Trusch, Hartmut Schlüter , Ingke Braren, Edzard Spillner , Martin Trepel PLoS One 5, e15922 (2010) |
| 34 |
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus Nick S. Laursen, Natasha Gordon, Stefan Hermans, Natalie Lorenz, Nicola Jackson, Bruce Wines, Edzard Spillner , Jesper B. Christensen, Morten Jensen, Folmer Fredslund, Mette Bjerre, Lars Sottrup-Jensen, John D. Fraser, Gregers R. Andersen Proceedings of the National Academy of Sciences of the United States of America 107, 3681-3686 (2010) |
2009 | |
| 33 |
Establishment of hapten-specific monoclonal avian IgY by conversion of antibody fragments obtained from combinatorial libraries Susanne Deckers, Ingke Braren, Kerstin Greunke, Nadine Meyer, Dana Rühl, Reinhard Bredehorst, Edzard Spillner Biotechnology and Applied Biochemistry 52, 79-87 (2009) |
| 32 |
Dissecting CCD reactivity in hymenoptera venom allergy by diminution of α-1,3-core fucosylation Simon Blank, Henning Seismann, Ingke Braren, Kerstin Greunke, Liliana Cifuentes, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Allergy 64 (Suppl. 90: Special Issue: Abstracts of the XXVIII EAACI Congress of the European Academy of Allergy and Clinical Immunology, Warszawa, Poland, 6-10 June 2009) 39-39 (79) (2009) |
| 31 |
Improvement of molecular diagnosis in hymenoptera venom hypersensitivity by the use of the recombinant major allergens Ves v 1 and Ves v 5 Henning Seismann, Simon Blank, Ingke Braren, Liliana Cifuentes, Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Edzard Spillner Allergy 64 (Suppl. 90: Special Issue: Abstracts of the XXVIII EAACI Congress of the European Academy of Allergy and Clinical Immunology, Warszawa, Poland, 6-10 June 2009) 39-39 (80) (2009) |
| 30 |
Chimeras of human IgE receptor a-chain and avian constant immunoglobulin domains for the determination of serum IgE Ingke Braren, Kerstin Greunke, Thomas Grunwald, Charles Pilette, Reinhard Bredehorst, Johannes Ring, Edzard Spillner , Markus W. Ollert Allergy 64 (Suppl. 90: Special Issue: Abstracts of the XXVIII EAACI Congress of the European Academy of Allergy and Clinical Immunology, Warszawa, Poland, 6-10 June 2009) 81-82 (174) (2009) |
| 29 |
Antibody compositions specific for IgE, IgG4 and IgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy Ingke Braren, Reinhard Bredehorst, Markus W. Ollert , Thomas Grunwald, Johannes Ring, Edzard Spillner Patent: EP 2022507 (A1) 2009-02-11 |
2008 | |
| 28 |
Recombinant IgY for improvement of immunoglobulin-based analytical applications Kerstin Greunke, Ingke Braren, Iris Alpers, Simon Blank, Jan Sodenkamp, Reinhard Bredehorst, Edzard Spillner Clinical Biochemistry 41, 1237-1244 (2008) |
| 27 |
Adaption und Modulation immunologischer Interaktionen für diagnostische und therapeutische Applikationen Edzard Spillner Habilitationsschrift, Hamburg (2008) |
| 26 |
Generation of a panel of monoclonal IgE antibodies with specificity for hymenoptera venom allergens Henning Seismann, Simon Blank, Ingke Braren, Thomas Grunwald, Reinhard Bredehorst, Markus W. Ollert , Edzard Spillner Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 13-13 (29) (2008) |
| 25 |
Identification, recombinant expression and characterisation of high molecular weight hymenoptera venom allergens Simon Blank, Henning Seismann, Benjamin Bockisch, Ingke Braren, Reinhard Bredehorst, Markus W. Ollert , Thomas Grunwald, Edzard Spillner Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 13-13 (30) (2008) |
| 24 |
Addressing current challenges of allergy diagnostics using recombinant human antibody isotypes Ingke Braren, J. Heckerv, Simon Blank, Henning Seismann, Dana Rühl, Reinhard Bredehorst, Thomas Grunwald, Markus W. Ollert , Edzard Spillner Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 42-43 (90) (2008) |
| 23 |
Up-regulation of CD63 in basophils from wasp venom-allergic patients by insect cell-expressed recombinant Antigen 5 (Ves v 5) Liliana Cifuentes, Lukas Balzer, Henning Seismann, Ingke Braren, Simon Blank, Edzard Spillner , Johannes Ring, Martin Mempel, Markus W. Ollert Allergy 63 (Suppl. 88: Special Issue: Abstracts of the XXVII EAACI Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain on 7-11 June 2008) 442-442 (1215) (2008) |
2007 | |
| 22 |
Comparative expression of different antibody formats in mammalian cells and Pichia pastoris Ingke Braren, Kerstin Greunke, Oliver Umland, Susanne Deckers, Reinhard Bredehorst, Edzard Spillner Biotechnology and Applied Biochemistry 47, 205-214 (2007) |
| 21 |
Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries Ingke Braren, Simon Blank, Henning Seismann, Susanne Deckers, Markus W. Ollert , Thomas Grunwald, Edzard Spillner Clinical Chemistry 53, 837-844 (2007) |
| 20 |
Purification
of native and recombinant Cobra Venom Factor using thiophilic adsorption chromatography Johanna Kölln, Ingke Braren, Reinhard Bredehorst, Edzard Spillner Protein & Peptide Letters 14, 475-480 (2007) |
| 19 |
Bivalent IgY antibody constructs for diagnostic and therapeutic applications Reinhard Bredehorst, Kerstin Greunke, Thomas Grunwald, Edzard Spillner Patent: EP 1757622 (A1) 2007-02-28 |
| 18 |
Method for determining an unknown PNA [peptide nucleic acid] sequence and uses thereof Reinhard Bredehorst, Jörn Glökler, Thomas Grunwald, Mark Matzas, Edzard Spillner Patent: EP 1785490 (A1) 2007-05-16 |
2006 | |
| 17 |
Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3) Thomas Grunwald, Benjamin Bockisch, Edzard Spillner , Johannes Ring, Reinhard Bredehorst, Markus W. Ollert Journal of Allergy and Clinical Immunology 117, 848-854 (2006) |
| 16 |
High level expression of monomeric and dimeric human α1,3-fucosyltransferase V Jan Münster, Patrick Ziegelmüller, Edzard Spillner , Reinhard Bredehorst Journal of Biotechnology 121, 448-457 (2006) |
| 15 |
Bivalent monoclonal IgY antibody formats by conversion of recombinant antibody fragments Kerstin Greunke, Edzard Spillner , Ingke Braren, Henning Seismann, Sabine Kainz, Ulrich Hahn , Thomas Grunwald, Reinhard Bredehorst Journal of Biotechnology 124, 446-456 (2006) |
| 14 |
Triosephosphate Isomerase- and Glyceraldehyde-3-Phosphate Dehydrogenase-Reactive Autoantibodies in the Cerebrospinal Fluid of Patients with Multiple Sclerosis Johanna Kölln, Hui-Min Ren, Reng-Rong Da, Yiping Zhang, Edzard Spillner , Michael Olek, Neal Hermanowicz, Lutz G. Hilgenberg, Martin A. Smith, Stanley van den Noort, Yufen Qin Journal of Immunology 177, 5652-5658 (2006) |
| 13 |
Detection of TNT-analog TNP-TRIS in immunoassay with two recombinant scFv-antibodies Mladen Simonovic, B. R. Simonovic, S. Zlatanovic-Milosevic, Edzard Spillner , Reinhard Bredehorst Physical Chemistry 2006, Proceedings of the International Conference on Fundamental and Applied Aspects of Physical Chemistry, 8th, Belgrade, Serbia, Sept. 26-29, 2006, 1, 440-442 (2006) |
| 12 |
Inactivation of complement by recombinant human C3 derivatives Edzard Spillner , Johanna Kölln, Reinhard Bredehorst Advances in Experimental Medicine and Biology 586 (Current Topics in Complement) 347-360 (2006) |
2005 | |
| 11 |
Engineering of human complement component C3 for catalytic inhibition of complement Johanna Kölln, Reinhard Bredehorst, Edzard Spillner Immunology Letters 98, 49-56 (2005) |
| 10 |
Malting barley grain non-specific lipid-transfer protein (ns-LTP): importance for grain protection Stanislava Gorjanovic, Edzard Spillner , Milos V. Beljanski, Radmila Gorjanovic, Mirjana Pavlovic, Gordana Gojgic-Cvijanovic Journal of the Institute of Brewing 111, 99-104 (2005) |
| 9 |
Rapid detection of viruses using electrical biochips and anti-virion sera Marcin Los, Joanna M. Los, Lars Blohm, Edzard Spillner , Thomas Grunwald, Jörg Albers, Rainer Hintsche, Grzegorz Wegrzyn Letters in Applied Microbiology 40, 479-485 (2005) |
| 8 |
Immobilized stem-loop structured probes as conformational switches for enzymatic detection of microbial 16S rRNA Benjamin Bockisch, Thomas Grunwald, Edzard Spillner , Reinhard Bredehorst Nucleic Acids Research 33, e101/1-e101/8 (2005) |
| 7 |
Complement depletion using recombinant human C3-derivatives Johanna Kölln, Reinhard Bredehorst, Edzard Spillner Patent: WO 2005003159 (A1) 2005-01-13 |
2004 | |
| 6 |
Complement Inactivation by Recombinant Human C3 Derivatives Johanna Kölln, Edzard Spillner , Jörg Andrä , Katrin Klensang, Reinhard Bredehorst Journal of Immunology 173, 5540-5545 (2004) |
| 5 |
Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells Johanna Kölln, Mark Matzas, Nathalie Janner, Thorsten Mix, Katrin Klensang, Reinhard Bredehorst, Edzard Spillner Molecular Immunology 41, 19-28 (2004) |
2003 | |
| 4 |
Paratope-based protein identification by antibody and peptide phage display Edzard Spillner , Susanne Deckers, Thomas Grunwald, Reinhard Bredehorst Analytical Biochemistry 321, 96-104 (2003) |
2002 | |
| 3 |
Selektion und Expression von rekombinanten Antikörpern für analytische und therapeutische Applikationen Edzard Spillner -/- Betreuer: Reinhard Bredehorst Dissertation, Hamburg (2002), ISBN 978-3-89873-607-7; 3-89873-607-5 , Verlag: Cuvillier, Göttingen |
1999 | |
| 2 |
Cleavage of palladium metallacycles by acids: a probe for the study of the cyclometalation reaction Juan Campora, Jorge A. Lopez, Pilar Palma, Pedro Valerga, Edzard Spillner , Ernesto Carmona Angewandte Chemie, International Edition 38, 147-151 (1999) |
1997 | |
| 1 |
pOVEX vector: prokaryotic expression and purification of onchocerciasis vaccine candidate antigens as fusion proteins with the 24 kD Onchocerca volvulus glutathione S-transferase Eva Liebau, Edzard Spillner , Kimberly Henkle-Dührsen Tropical Medicine & International Health 2, 691-694 (1997) |