Fachbereich Chemie
Publikationen von Ralph Holl
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| Suche: FB Chemie / Hamburg | |
| 2024 | |
| 36 |
Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity Sebastian Mielniczuk, Katharina Hoff, Fady Baselious, Yunqi Li, Jörg Haupenthal, Andreas M. Kany, Maria Riedner , Holger Rohde , Katharina Rox, Anna K. H. Hirsch, Isabelle Krimm, Wolfgang Sippl, Ralph Holl Journal of Medicinal Chemistry 67, 17363-17391 (2024) |
2023 | |
| 35 |
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors Stefan Wimmer, Katharina Hoff, Benedikt Martin, Martin Grewer, Laura Denni, Raquel Lascorz Massanet, Maria Valeria Raimondi, Emre F. Bülbül, Jelena Melesina, Sven-Kevin Hotop, Jörg Haupenthal, Holger Rohde , Peter Heisig, Anna K. H. Hirsch, Mark Brönstrup, Wolfgang Sippl, Ralph Holl Bioorganic Chemistry 131, 106331 (2023) |
| 34 |
Editorial: Emerging heterocycles as bioactive compounds Giovanna Li Petri, Ralph Holl , Virginia Spanò, Marilia Barreca, Ignazio Sardo, Maria Valeria Raimondi Frontiers in Chemistry 11, 1202192 (3 pp) (2023) |
2021 | |
| 33 |
Antibacterial activity of xylose-derived LpxC inhibitors - Synthesis, biological evaluation and molecular docking studies Alexander Dreger, Katharina Hoff, Oriana Agoglitta, Sven-Kevin Hotop, Mark Brönstrup, Peter Heisig, Johannes Kirchmair , Ralph Holl Bioorganic Chemistry 107, 104603 (15 pp) (2021) |
| 32 |
Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors Alexander Dreger, Katharina Hoff, Oriana Agoglitta, Emre F. Bülbül, Jelena Melesina, Wolfgang Sippl, Ralph Holl Bioorganic Chemistry 117, 105403 (15 pp) (2021) |
| 31 |
Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds Giovanna Li Petri, Maria Valeria Raimondi, Virginia Spanò, Ralph Holl , Paola Barraja, Alessandra Montalbano Topics in Current Chemistry 379, 34 (46 pp) (2021) |
2020 | |
| 30 |
Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors Katharina Hoff, Sebastian Mielniczuk, Oriana Agoglitta, Maria Teresa Iorio, Manlio Caldara, Emre F. Bülbül, Jelena Melesina, Wolfgang Sippl, Ralph Holl Bioorganic & Medicinal Chemistry 28, 115529 (15 pp) (2020) |
| 29 |
Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors Ralph Holl , Dmitrii V. Kalinin, Sunit Kumar Jana, Maxim Pfafenrot, Alokta Chakrabarti, Jelena Melesina, Tajith Baba Shaik, Julien Lancelot, Raymond J. Pierce, Wolfgang Sippl, Christophe Romier, Manfred Jung ChemMedChem 15, 571-584 (2020) Cover Picture: ChemMedChem 15, 559-559 (2020) |
| 28 |
Bioactive pyrrole-based compounds with target selectivity Giovanna Li Petri, Virginia Spanò, Roberto Spatola, Ralph Holl , Maria Valeria Raimondi, Paola Barraja, Alessandra Montalbano European Journal of Medicinal Chemistry 208, 112783 (2020) |
2019 | |
| 27 |
Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies Dmitrii V. Kalinin, Oriana Agoglitta, Helene van de Vyver, Jelena Melesina, Stefan Wagner, Burkhard Riemann, Michael Schäfers, Wolfgang Sippl, Bettina Löffler, Ralph Holl Bioorganic & Medicinal Chemistry 27, 1997-2018 (2019) |
| 26 |
Chiral pool synthesis, biological evaluation and molecular docking studies of C-furanosidic LpxC inhibitors Alexander Dreger, Omar Kharwb, Oriana Agoglitta, Emre F. Bülbül, Jelena Melesina, Wolfgang Sippl, Ralph Holl ChemMedChem 14, 871-886 (2019) |
| 25 |
Phenylethylene glycol-derived LpxC inhibitors with diverse Zn2+-binding groups Magdalena Galster, Marius Löppenberg, Fabian Galla, Frederik Börgel, Oriana Agoglitta, Johannes Kirchmair , Ralph Holl Tetrahedron 75, 486-509 (2019) |
2018 | |
| 24 |
Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants Martin Marek, Tajith Baba Shaik, Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Elizabeth Ramos Morales, Cyrielle Da Veiga, Dmitrii V. Kalinin, Jelena Melesina, Dina Robaa, Karin Schmidtkunz, Takayoshi Suzuki, Ralph Holl , Eric Ennifar, Raymond J. Pierce, Manfred Jung, Wolfgang Sippl, Christophe Romier Journal of Medicinal Chemistry 61, 10000-10016 (2018) |
2017 | |
| 23 |
LpxC inhibitors: a patent review (2010-2016) Dmitrii V. Kalinin, Ralph Holl Expert Opinion on Therapeutic Patents 27, 1227-1250 (2017) |
2016 | |
| 22 |
Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors Giovanni Tangherlini, Tullio Torregrossa, Oriana Agoglitta, Jens Köhler, Jelena Melesina, Wolfgang Sippl, Ralph Holl Bioorganic & Medicinal Chemistry 24, 1032-1044 (2016) |
| 21 |
Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design Dmitrii V. Kalinin, Ralph Holl Current Topics in Medicinal Chemistry 16, 2379-2430 (2016) |
| 20 |
Chiral pool synthesis and biological evaluation of C-furanosidic and acyclic LpxC inhibitors Hannes Müller, Valeria Gabrielli, Oriana Agoglitta, Ralph Holl European Journal of Medicinal Chemistry 110, 340-375 (2016) |
| 19 |
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography Dmitrii V. Kalinin, Stefan Wagner, Burkhard Riemann, Sven Hermann, Frederike Schmidt, Christoph Becker-Pauly, Stefan Rose-John, Michael Schäfers, Ralph Holl Journal of Medicinal Chemistry 59, 9541-9559 (2016) |
| 18 |
Synthese, biologische Testung und Struktur-Wirkungs-Beziehungen von Inhibitoren der bakteriellen Deacetylase LpxC Ralph Holl Habilitationsschrift, Münster (2016) |
2015 | |
| 17 |
Synthesis and biological evaluation of C-ethynyl furanosides as LpxC inhibitors Sunit Kumar Jana, Marius Löppenberg, Constantin G. Daniliuc, Ralph Holl Tetrahedron 71, 956-966 (2015) |
2014 | |
| 16 |
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors Marina Szermerski, Jelena Melesina, Kanin Wichapong, Marius Löppenberg, Joachim Jose, Wolfgang Sippl, Ralph Holl Bioorganic & Medicinal Chemistry 22, 1016-1028 (2014) |
| 15 |
C-Triazolyl β-D-furanosides as LpxC inhibitors: stereoselective synthesis and biological evaluation Sunit Kumar Jana, Marius Löppenberg, Constantin G. Daniliuc, Ralph Holl Tetrahedron 70, 6569-6577 (2014) |
2013 | |
| 14 |
Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors Marius Löppenberg, Hannes Müller, Carla Pulina, Alberto Oddo, Mark Teese, Joachim Jose, Ralph Holl Organic & Biomolecular Chemistry 11, 6056-6070 (2013) |
| 13 |
Development of novel LpxC inhibitors: chiral-pool synthesis of C-triazolyl glycosides Sunit Kumar Jana, Marius Löppenberg, Constantin G. Daniliuc, Joachim Jose, Ralph Holl Tetrahedron 69, 9434-9442 (2013) |
2012 | |
| 12 |
Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analog Alberto Oddo, Ralph Holl Carbohydrate Research 359, 59-64 (2012) |
| 11 |
Stereocontrolled synthesis of four diastereomeric C-aryl manno- and talofuranosides Elisa Ravarino, Sunit Kumar Jana, Roland Fröhlich, Ralph Holl Carbohydrate Research 361, 162-169 (2012) |
| 10 |
Homologous piperazine-alkanols: chiral pool synthesis and pharmacological evaluation Ralph Holl , Dirk Schepmann, Bernhard Wünsch MedChemComm 3, 673-679 (2012) |
2011 | |
| 9 |
Structure and function of an irreversible agonist-β2 adrenoceptor complex Daniel M. Rosenbaum, Cheng Zhang, Joseph A. Lyons, Ralph Holl , David Aragao, Daniel H. Arlow, Soren G. F. Rasmussen, Hee-Jung Choi, Brian T. DeVree, Roger K. Sunahara, Pil Seok Chae, Samuel H. Gellman, Ron O. Dror, David E. Shaw, William I. Weis, Martin Caffrey, Peter Gmeiner, Brian K. Kobilka Nature 469 (7329) 236-240 (2011) |
2009 | |
| 8 |
Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their .sigma. receptor affinity and cytotoxic activity Ralph Holl , Dirk Schepmann, Renate Grünert, Patrick J. Bednarski, Bernhard Wünsch Bioorganic & Medicinal Chemistry 17, 777-793 (2009) |
| 7 |
Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their .sigma. receptor affinity and cytotoxic activity Ralph Holl , Dirk Schepmann, Patrick J. Bednarski, Renate Grünert, Bernhard Wünsch Bioorganic & Medicinal Chemistry 17, 1445-1455 (2009) |
| 6 |
Structure-affinity-relationship study of bicyclic .sigma. receptor ligands Ralph Holl , Christian Geiger, Masakazu Nambo, Kenichiro Itami, Dirk Schepmann, Bernhard Wünsch Central Nervous System Agents in Medicinal Chemistry 9, 220-229 (2009) |
| 5 |
Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring Ralph Holl , Bettina Jung, Dirk Schepmann, Hans-Ulrich Humpf, Renate Grünert, Patrick J. Bednarski, Werner Englberger, Bernhard Wünsch ChemMedChem 4, 2111-2122 (2009) |
| 4 |
Dancing of the Second Aromatic Residue around the 6,8-Diazabicyclo[3.2.2]nonane Framework: Influence on s Receptor Affinity and Cytotoxicity Ralph Holl , Dirk Schepmann, Roland Fröhlich, Renate Grünert, Patrick J. Bednarski, Bernhard Wünsch Journal of Medicinal Chemistry 52, 2126-2137 (2009) |
2008 | |
| 3 |
Synthesis of 2,5-Diazabicyclo[2.2.2]octanes by Dieckmann Analogous Cyclization Ralph Holl , Mareike Dykstra, Martin Schneiders, Roland Fröhlich, Masato Kitamura, Ernst-Ulrich Würthwein, Bernhard Wünsch Australian Journal of Chemistry 61, 914-919 (2008) |
| 2 |
A new, efficient and direct preparation of TlTp and related complexes with TlBH4 Masato Kitamura, Yuta Takenaka, Tomoko Okuno, Ralph Holl , Bernhard Wünsch European Journal of Inorganic Chemistry 1188-1192 (2008) |
| 1 |
.sigma.- und δ-Rezeptor-Liganden mit überbrückter Piperazin-Struktur: Synthese und Struktur-Wirkungs-Beziehungen Ralph Holl -/- Betreuer: Bernhard Wünsch Dissertation, Münster (2008) |