Department of Chemestry
Short biography and Publications by Conrad Kunick
Short biography
| 1960 | born in Hamburg |
| 1986 | PhD with Paul Messinger in Hamburg |
| 2000 | Habilitation in Hamburg |
| 2003- | TU Braunschweig |
Further Information
Publications
(only until the end of Hamburg time, until 2003)
.
| Search: Chemistry Dep. / all Hamburg | |
| 2004 | |
| 46 |
CDK1-inhibitory activity of paullones depends on electronic properties of 9-substituents Tanja Pies, Klaus-Jürgen Schaper, Maryse Leost, Daniel W. Zaharevitz, Rick Gussio, Laurent Meijer, Conrad Kunick Archiv der Pharmazie 337, 486-492 (2004) |
| 45 |
Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localization and selective inhibitors Eliane Droucheau, Aline Primot, Virginie Thomas, Denise Mattei, Marie Knockaert, Chris Richardson, Pina Sallicandro, Pietro Alano, Ali Jafarshad, Blandine Baratte, Conrad Kunick , Daniel Parzy, Laurence H. Pearl, Christian Doerig, Laurent Meijer Biochimica et Biophysica Acta, Proteins and Proteomics 1697, 181-196 (2004) Erratum: Biochimica et Biophysica Acta, Proteins and Proteomics 1700, 139-140 (2004) |
| 44 |
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β Conrad Kunick , Kathrin Lauenroth, Maryse Leost, Laurent Meijer, Thomas Lemcke Bioorganic & Medicinal Chemistry Letters 14, 413-416 (2004) |
| 43 |
Novel molecular targets in cancer chemotherapy waiting for discovery Conrad Kunick Current Medicinal Chemistry: Anti-Cancer Agents 4, 421-423 (2004) |
| 42 |
Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones Conrad Kunick , Kathrin Lauenroth, Karen Wieking, Xu Xie, Christiane Schultz, Rick Gussio, Daniel W. Zaharevitz, Maryse Leost, Laurent Meijer, Alexander Weber, Flemming Steen Jørgensen, Thomas Lemcke Journal of Medicinal Chemistry 47, 22-36 (2004) |
2003 | |
| 41 |
Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential Tyler Lahusen, Adriana De Siervi, Conrad Kunick , Adrian M. Senderowicz Molecular Carcinogenesis 36, 183-194 (2003) |
| 40 |
Professor Dr. Detlef Geffken, 60 Jahre (Professor Dr. Detlef Geffken, 60 years) Conrad Kunick , Jobst B. Mielck Pharmazeutische Zeitung 148, 1494-1495 (2003) |
2002 | |
| 39 |
Synthesis of paullones with aminoalkyl side chains Karen Wieking, Marie Knockaert, Maryse Leost, Daniel W. Zaharevitz, Laurent Meijer, Conrad Kunick Archiv der Pharmazie 335, 311-317 (2002) |
| 38 |
Intracellular targets of paullones. Identification following affinity purification on immobilized inhibitor Marie Knockaert, Karen Wieking, Sophie Schmitt, Maryse Leost, Karen M. Grant, Jeremy C. Mottram, Conrad Kunick , Laurent Meijer Journal of Biological Chemistry 277, 25493-25501 (2002) |
| 37 |
Paullone als selektive Kinase-Inhibitoren (Drug research: paullones as selective kinase inhibitors) Conrad Kunick , Thomas Lemcke Pharmazeutische Zeitung 147, 2428-2435 (2002) |
| 36 |
Fused azepinone cyclin dependent kinase inhibitors Daniel W. Zaharevitz, Rick Gussio, Ravi K. Jalluri, Edward A. Sausville, Conrad Kunick , Laurent Meijer Patent: US 20020042412 (A1) 2002-04-11 |
2001 | |
| 35 |
Aryl rings are part of the darpone pharmacophore Christiane Schultz, Andreas Link , Conrad Kunick Archiv der Pharmazie 334, 163-166 (2001) |
| 34 |
Biotin labelling of amines by polymer-assisted solution-phase synthesis Abolfasl Golisade, Claudia Herforth, Karen Wieking, Conrad Kunick , Andreas Link Bioorganic & Medicinal Chemistry Letters 11, 1783-1786 (2001) |
| 33 |
Use of paullone derivatives for making medicines Laurent Meijer, Conrad Kunick Patent: WO 2001060374 (A1) 2001-08-23 |
2000 | |
| 32 |
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition Rick Gussio, Daniel W. Zaharevitz, Connor F. McGrath, Nagarajan Pattabiraman, Glen E. Kellogg, Christiane Schultz, Andreas Link , Conrad Kunick , Maryse Leost, Laurent Meijer, Edward A. Sausville Anti-Cancer Drug Design 15, 53-66 (2000) |
| 31 |
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in-vitro antiproliferative activity Conrad Kunick , Christiane Schultz, Thomas Lemcke, Daniel W. Zaharevitz, Rick Gussio, Ravi K. Jalluri, Edward A. Sausville, Maryse Leost, Laurent Meijer Bioorganic & Medicinal Chemistry Letters 10, 567-569 (2000) |
| 30 |
Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25 Maryse Leost, Christiane Schultz, Andreas Link , Yong-Zhong Wu, Jacek Biernat, Eva-Maria Mandelkow , James A. Bibb, Gretchen L. Snyder, Paul Greengard, Daniel W. Zaharevitz, Rick Gussio, Adrian M. Senderowicz, Edward A. Sausville, Conrad Kunick , Laurent Meijer European Journal of Biochemistry 267, 5983-5994 (2000) |
| 29 |
Paullone und verwandte anellierte Azepinone mit antiproliferativer Aktivität Conrad Kunick Habilitationsschrift, Hamburg (2000) |
| 28 |
Structure-based, 3D, quantitative structure activity relationship between paullones and CDK5/p25 Rick Gussio, Connor F. McGrath, Daniel W. Zaharevitz, Glen E. Kellogg, Christiane Schultz, Conrad Kunick , Maryse Leost, Laurent Meijer, Edward A. Sausville Abstracts of Papers, 220th ACS National Meeting, Washington, DC, United States, August 20-24, 2000 COMP-C097 (2000) |
| 27 |
Medicaments containing hydroxy-benzo-cyclopentabenzazepine-dione derivatives, useful as cellular hyperproliferation inhibitors, especially antitumor agents Conrad Kunick , Carola Bleeker Patent: DE 19910403 (A1) 2000-09-07 |
1999 | |
| 26 |
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases Daniel W. Zaharevitz, Rick Gussio, Maryse Leost, Adrian M. Senderowicz, Tyler Lahusen, Conrad Kunick , Laurent Meijer, Edward A. Sausville Cancer Research 59, 2566-2569 (1999) |
| 25 |
Fused Azepinones with Antitumor Activity Conrad Kunick Current Pharmaceutical Design 5, 181-194 (1999) |
| 24 |
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity Christiane Schultz, Andreas Link , Maryse Leost, Daniel W. Zaharevitz, Rick Gussio, Edward A. Sausville, Laurent Meijer, Conrad Kunick Journal of Medicinal Chemistry 42, 2909-2919 (1999) |
| 23 |
Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target Edward A. Sausville, Daniel W. Zaharevitz, Robert Gussio, Laurent Meijer, Maryse Louarn-Leost, Conrad Kunick , Robert Schultz, Tyler Lahusen, Donna Headlee, Sherman Stinson, Susan G. Arbuck, Adrian M. Senderowicz Pharmacology & Therapeutics 82, 285-292 (1999) |
| 22 |
Antitumor pyrido[3,2-d][1]benzazepines. Synthesis and in vitro activity of thiophene analogs Andreas Link , Daniel W. Zaharevitz, Conrad Kunick Pharmazie 54, 163-166 (1999) |
| 21 |
Naphthannelated azepinones. Synthesis and antitumor activity Carola Bleeker, Conrad Kunick Pharmazie 54, 645-650 (1999) |
| 20 |
Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1 Serge van Calenbergh, Andreas Link , Conrad Kunick , Piet Herdewijn Pharmazie 54, 727-729 (1999) |
| 19 |
Preparation of indolobenzazepinones and related compounds as cyclin dependent kinase inhibitors Conrad Kunick , Laurent Meijer, Daniel W. Zaharevitz, Rick Gussio, Ravi K. Jalluri, Edward A. Sausville Patent: WO 9965910 (A1) 1999-12-23 |
1998 | |
| 18 |
d-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity: Synthesis and Structure-Activity Relationships Andreas Link , Conrad Kunick Journal of Medicinal Chemistry 41, 1299-1305 (1998) |
1997 | |
| 17 |
Preparation of spiro[1-benzazepine-4,1'-cyclohexane] derivatives from 1H-1-benzazepine-2,5(3H,4H)-diones and Mannich bases Andreas Link , Conrad Kunick Synthesis 297-300 (1997) |
1996 | |
| 16 |
Synthesis and in vivo testing of a potential aquaretic agent Conrad Kunick , Andreas Link , Max Hropot Pharmazie 51, 601-602 (1996) |
1995 | |
| 15 |
Fused [1]benzazepines. Pentacyclic [1]benzazepines by reaction of 1H-[1]benzazepine-2,5(3H,4H)-dione with aldehydes Conrad Kunick Heterocycles 41, 2299-2306 (1995) |
| 14 |
Synthesis of pyrido[3,4-d]benzazepines Conrad Kunick , Andreas Link Journal of Heterocyclic Chemistry 32, 803-805 (1995) |
1994 | |
| 13 |
Benazepril, ein neuer ACE-Hemmer (Benazepril, a new ACE inhibitor) Conrad Kunick Pharmazeutische Zeitung 139, 26-29 (1994) |
| 12 |
Proguanil, ein Malariamittel (Proguanil. An antimalaria agent) Conrad Kunick Pharmazeutische Zeitung 139, 2908-2913 (1994) |
1993 | |
| 11 |
Synthese und konformative Flexibilität von 4,9-Dihydroindolo[3,2-d][1,2,4]triazolo[4,3-a]benzazepinen (Synthesis and conformational flexibility of 4,9-dihydroindolo[3,2-d][1,2,4]triazolo[4,3-a][1]benzazepines) Conrad Kunick Liebigs Annalen der Chemie 1141-1143 (1993) |
| 10 |
Remoxiprid - ein Neuroleptikum (Remoxipride - a neuroleptic) Conrad Kunick Pharmazeutische Zeitung 138, 428-434 (1993) |
1992 | |
| 9 |
Synthese von 7,12-Dihydro-indolo[3,2-d][1]benzazepin-6-(5H)-onen und 6,11-Dihydro-thieno-[3',2':2,3]azepino[4,5-b]indol-5(4H)-on (Synthesis of 7,12-dihydroindolo[3,2-d][1]benzazepin-6-(5H)-ones and 6,11-dihydrothieno[3',2':2,3]azepino[4,5-b]indol-5(4H)-one) Conrad Kunick Archiv der Pharmazie 325, 297-299 (1992) |
| 8 |
Idarubicin - ein Zytostaticum (Idarubicin - a cytostatic) Conrad Kunick Pharmazeutische Zeitung 137, 2124-2131 (1992) |
1991 | |
| 7 |
Synthese [b]-kondensierter Azepindione durch Dealkoxycarbonylierung (Synthesis of [b]-fused azepinediones by dealkoxycarbonylation) Conrad Kunick Archiv der Pharmazie 324, 579-581 (1991) |
1989 | |
| 6 |
Esperamicine
und Calichemicine - neue hochwirksame Antitumorwirkstoffe (Esperamicins and calichemicins: new highly active antitumor agents) Conrad Kunick , Martin Schulz Pharmazeutische Zeitung 134, 1318-1323 (1989) |
1986 | |
| 5 |
Deuterierung enolisierbarer Ketone mit Deuterochloroform (Deuteration of enolizable ketones with deuterochloroform) Conrad Kunick , Paul Messinger Chemische Berichte 119, 1429-1431 (1986) |
| 4 |
Eine bequeme Synthese von 2-Aroyl-5-arylpyrrolen (A convenient synthesis of 2-aroyl-5-arylpyrroles) Paul Messinger, Conrad Kunick Synthesis 213-214 (1986) |
| 3 |
Darstellung und Umwandlung α-substituierter β-Oxosulfoxide Conrad Kunick -/- Supervisor: Paul Messinger Dissertation, Hamburg (1986) |
1985 | |
| 2 |
2-Sulfinyl-pentan-1,5-dione aus β-Oxosulfoxiden (2-Sulfinylpentane-1,5-diones from β-oxo sulfoxides) Paul Messinger, Conrad Kunick Archiv der Pharmazie 318, 1045-1048 (1985) |
| 1 |
Additionsreaktionen von β-Ketosulfoxiden und Bis(phenylsulfinyl)methan an Isocyanate (Addition reactions of β-keto sulfoxides and bis(phenylsulfinyl)methane to isocyanates) Paul Messinger, Conrad Kunick Archiv der Pharmazie 318, 1086-1090 (1985) |