Department of Chemestry
Publications by Thomas Lemcke
.
| Search: Chemistry Dep. / all Hamburg | |
| 2023 | |
| 30 |
Tag der Pharmazie 2023 Thomas Lemcke CU - Chemie UniHamburg - Die Mitarbeiterzeitung (32) 31-31 (2023) |
2022 | |
| 29 |
Tag der Pharmazie Thomas Lemcke CU - Chemie UniHamburg - Die Mitarbeiterzeitung (30) 8-8 (2022) (Subject: Christan Ducho) |
2021 | |
| 28 |
Regulation of dual leucine zipper kinase activity through its interaction with calcineurin Jorge Duque Escobar, Anna Kutschenko, Sabine Schröder, Roland Blume, Kyra-Alexandra Köster, Christina Painer, Thomas Lemcke, Wolfgang Maison , Elke Oetjen Cellular Signalling 82, 109953 (2021) |
2016 | |
| 27 |
Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015) Elke Oetjen , Thomas Lemcke Expert Opinion on Therapeutic Patents 26, 607-616 (2016) |
2013 | |
| 26 |
3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles Are Selective Inhibitors of Plasmodium falciparum Glycogen Synthase Kinase-3 Wiebke Fugel, Anselm Erich Oberholzer, Bernhard Gschloessl, Ron Dzikowski, Narkiss Pressburger, Lutz Preu, Laurence H. Pearl, Blandine Baratte, Morgane Ratin, Ilya Okun, Christian Doerig, Sebastian Kruggel, Thomas Lemcke, Laurent Meijer, Conrad Kunick Journal of Medicinal Chemistry 56, 264-275 (2013) |
2011 | |
| 25 |
Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Conrad Kunick European Journal of Medicinal Chemistry 46, 2759-2769 (2011) |
| 24 |
Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening Thomas Lemcke, Jan Dreher, Matthias Rarey , Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Conrad Kunick Molecular Informatics 30, 145-150 (2011) |
2010 | |
| 23 |
Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold Wiebke Brandt, Luca Mologni, Lutz Preu, Thomas Lemcke, Carlo Gambacorti-Passerini, Conrad Kunick European Journal of Medicinal Chemistry 45, 2919-2927 (2010) |
| 22 |
The search for the right pose. A straightforward workflow for gsk-3 inhibitors Thomas Lemcke, Sebastian Kruggel DPhG Jahrestagung 2010, 4.-7. Oktober 2010, Braunscheig, Tagungsband C166 (2010), ISBN 978-3-927115-66-8 , Publisher: Deutsche Pharmazeutische Gesellschaft, Braunschweig |
| 21 |
Binding mode prediction of pfgsk-3 inhibitors with a thieno[2,3-B]pyridine scaffold Sebastian Kruggel, Thomas Lemcke DPhG Jahrestagung 2010, 4.-7. Oktober 2010, Braunscheig, Tagungsband C167 (2010), ISBN 978-3-927115-66-8 , Publisher: Deutsche Pharmazeutische Gesellschaft, Braunschweig |
2009 | |
| 20 |
Generation and Evaluation of a Homology Model of PfGSK-3 Sebastian Kruggel, Thomas Lemcke Archiv der Pharmazie 342, 327-332 (2009) |
| 19 |
Comparative Investigation of the ATP-Binding Site of Human and Plasmodial Glycogen Synthase Kinase-3 Sebastian Kruggel, Thomas Lemcke QSAR & Combinatorial Science 28, 885-890 (2009) |
2008 | |
| 18 |
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication Hendrik Stukenbrock, Rainer Mussmann, Marcus Geese, Yoan Ferandin, Olivier Lozach, Thomas Lemcke, Simone Kegel, Alexander Lomow, Ulrike Burk, Cord Dohrmann, Laurent Meijer, Matthias Austen, Conrad Kunick Journal of Medicinal Chemistry 51, 2196-2207 (2008) |
| 17 |
Characterization of the Quinolone-Gyrase-Interaction Using Docking, Molecular-Dynamics and Site-Directed Mutagenesis Jörn Lenz, Thomas Lemcke, Peter Heisig, Andrew E. Torda -/- Editor: Ulrich H. E. Hansmann, Jan H. Meinke, Sandipan Mohanty, Walter Nadler, Olav Zimmermann From Computational Biophysics to Systems Biology (CBSB08). Proceedings of the NIC Workshop 2008, 40, 289-292 (2008), ISBN 978-3-9810843-6-8 , Publisher: John von Neumann Institute for Computing, Jülich |
2007 | |
| 16 |
Development, selectivity, and application of paullones, a family of CDK inhibitors Conrad Kunick , Thomas Lemcke, Laurent Meijer -/- Editor: Paul J. Smith, Eddy W. Yue Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents 227-249 (2007), ISBN 9780849337741 , Publisher: CRC Press |
2006 | |
| 15 |
Novel kinase inhibitors derived from the structure-aided optimization of alsterpaullone Conrad Kunick , Zhihong Zeng, Rick Gussio, Daniel W. Zaharevitz, Maryse Leost, Laurent Meijer, Thomas Lemcke QSAR and Molecular Modelling in Rational Design of Bioactive Molecules, Proceedings of the European Symposium on Structure-Activity Relationships (QSAR) and Molecular Modelling, 15th, Istanbul, Turkey, Sept. 5-10, 2004, 505-507 (2006) |
2005 | |
| 14 |
Structure-aided optimization of kinase inhibitors derived from alsterpaullone Conrad Kunick , Zhihong Zeng, Rick Gussio, Daniel W. Zaharevitz, Maryse Leost, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Laurent Meijer, Thomas Lemcke ChemBioChem 6, 541-549 (2005) |
| 13 |
Epoxide-containing side chains enhance antiproliferative activity of paullones Xu Xie, Thomas Lemcke, Rick Gussio, Daniel W. Zaharevitz, Maryse Leost, Laurent Meijer, Conrad Kunick European Journal of Medicinal Chemistry 40, 655-661 (2005) |
| 12 |
Homology model of the CDK1/cyclin B complex Connor F. McGrath, Nagarajan Pattabiraman, Glen E. Kellogg, Thomas Lemcke, Conrad Kunick , Edward A. Sausville, Daniel W. Zaharevitz, Rick Gussio Journal of Biomolecular Structure and Dynamics 22, 493-502 (2005) |
2004 | |
| 11 |
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β Conrad Kunick , Kathrin Lauenroth, Maryse Leost, Laurent Meijer, Thomas Lemcke Bioorganic & Medicinal Chemistry Letters 14, 413-416 (2004) |
| 10 |
Evaluation and Comparison of 3D-QSAR CoMSIA Models for CDK1, CDK5, and GSK-3 Inhibition by Paullones Conrad Kunick , Kathrin Lauenroth, Karen Wieking, Xu Xie, Christiane Schultz, Rick Gussio, Daniel W. Zaharevitz, Maryse Leost, Laurent Meijer, Alexander Weber, Flemming Steen Jørgensen, Thomas Lemcke Journal of Medicinal Chemistry 47, 22-36 (2004) |
2002 | |
| 9 |
Paullone als selektive Kinase-Inhibitoren (Drug research: paullones as selective kinase inhibitors) Conrad Kunick , Thomas Lemcke Pharmazeutische Zeitung 147, 2428-2435 (2002) |
2001 | |
| 8 |
Synthesis and antibacterial activity of 5- and 6-hydroxy substituted 4-aminoquinolines and derivatives Thomas Meyer, Thomas Lemcke, Detlef Geffken, Paul-Michael Kaulfers Pharmazie 56, 691-695 (2001) |
2000 | |
| 7 |
2-Substituted paullones: CDK1/cyclin B-inhibiting property and in-vitro antiproliferative activity Conrad Kunick , Christiane Schultz, Thomas Lemcke, Daniel W. Zaharevitz, Rick Gussio, Ravi K. Jalluri, Edward A. Sausville, Maryse Leost, Laurent Meijer Bioorganic & Medicinal Chemistry Letters 10, 567-569 (2000) |
| 6 |
Towards the understanding of species selectivity and resistance of antimalarial DHFR inhibitors Thomas Lemcke, Inge Thøger Christensen, Flemming Steen Jørgensen Molecular Modeling and Prediction of Bioactivity, [Proceedings of the European Symposium on Quantitative Structure-Activity Relationships: Molecular Modeling and Prediction of Bioactivity], 12th, Copenhagen, Denmark, Aug. 23-28, 1998, 357-358 (2000) |
1999 | |
| 5 |
Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building Thomas Lemcke, Inge Thøger Christensen, Flemming Steen Jørgensen Bioorganic & Medicinal Chemistry 7, 1003-1011 (1999) |
1996 | |
| 4 |
Homology modelling of dihydrofolate reductase from the malaria parasite Thomas Lemcke, Inge Thøger Christensen, Flemming Steen Jørgensen European Journal of Pharmaceutical Sciences 4 (Suppl. 1) S105-S105 (1996) |
1995 | |
| 3 |
Sulfonylsubstituierte Heterocyclen aus β-Oxo-β-sulfonyl-enolethern und Amidinen, Hydrazinen oder Hydroxylamin (Sulfonyl substituted heterocycles from β-oxo-β-sulfonylenolethers and amidines, hydrazines, or hydroxylamine) Thomas Lemcke, Paul Messinger Archiv der Pharmazie 328, 269-270 (1995) |
1994 | |
| 2 |
Darstellung sulfonylsubstituierter Heterocyclen durch Cyclokondensation von Sulfonen mit bifunktionellen Verbindungen (Synthesis of sulfonyl-substituted heterocycles by cyclocondensation of sulfones with bifunctionalized compounds) Thomas Lemcke, Paul Messinger Journal für Praktische Chemie/Chemiker-Zeitung 336, 1-4 (1994) |
1988 | |
| 1 |
Darstellung sulfonylsubstituierter Heterocyclen Thomas Lemcke -/- Supervisor: Paul Messinger Dissertation, Hamburg (1988) |