Department of Chemestry
Short biography and Publications by Andreas Link
Short biography
| 1967 | born on 20. January 1967 in Flensburg |
| 1993 | Licence to practise as a pharmacist |
| 1996 | PhD with Conrad Kunick in Hamburg |
| 1996-1997 | PostDoc with Piet Herdewijn at the Rega Institute for Medical Research in Leuven, Belgium |
| 1997 | Glaxo Wellcome Innovation Prize for the Hamburg Pharmacy 1995/1996 |
| 2001 | Innovation Award of the GDCh Division of Medical Chemistry and the Division of Pharmaceutical/Medical Chemistry of the DPhG |
| 2002 | Habilitation in Hamburg |
| 2002 | Substitute Professorship (C3) at the Institute for Pharmaceutical Chemistry, Department of Pharmacy, Philipps University of Marburg |
| 2002-2004 | Professorship for Pharmaceutical Chemistry (C3) Successor to Prof. Dr. Manfred Haake, at the Department of Pharmacy, Philipps University of Marburg |
| 2004- | Professorship for Pharmaceutical/Medical Chemistry (C4) Successor Prof. Dr. Hans-Hartwig Otto at the Institute of Pharmacy of the Ernst-Moritz-Arndt-University Greifswald |
Further Information
Publications
(only until the end of Hamburg time, until 2002)
.
| Search: Chemistry Dep. / all Hamburg | |
| 2002 | |
| 33 |
Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker Abolfasl Golisade, Claudia Herforth, Ludo Quirijnen, Louis Maes, Andreas Link Bioorganic & Medicinal Chemistry 10, 159-165 (2002) |
| 32 |
Anti-Malarial activity of N6-Substituted adenosine derivatives. Part I Abolfasl Golisade, Jochen Wiesner, Claudia Herforth, Hassan Jomaa, Andreas Link Bioorganic & Medicinal Chemistry 10, 769-777 (2002) |
| 31 |
Dynamite
approach to delicate complex scaffolds Andreas Link Drug Discovery Today 7, 548-549 (2002) |
| 30 |
Antimalarial Activity of N6-Substituted Adenosine Derivatives (Part 2) Claudia Herforth, Jochen Wiesner, Stephan Franke, Abolfasl Golisade, Hassan Jomaa, Andreas Link Journal of Combinatorial Chemistry 4, 302-314 (2002) |
| 29 |
5'-Deoxy Congeners of 9-(3-Amido-3-deoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine: New Adenosine A1 Receptor Antagonists and Inverse Agonists Serge van Calenbergh, Andreas Link , Shelly Fujikawa, Rianne A. F. de Ligt, Veerle Vanheusden, Abolfasl Golisade, Norbert M. Blaton, Jef Rozenski, Adriaan P. IJzerman, Piet Herdewijn Journal of Medicinal Chemistry 45, 1845-1852 (2002) |
| 28 |
Triptane - neuere Entwicklungen: In der Pipeline (In the pipeline: triptans - newer developments) Andreas Link , Britta Link Pharmazie in Unserer Zeit 31, 486-493 (2002) |
| 27 |
Konvergente polymerunterstützte Parallelsynthese von Adenosinanaloga Andreas Link Habilitationsschrift, Hamburg (2002) |
| 26 |
Amine-modified nucleosides as adenosine A3 neoceptor ligands Philippe van Rompaey, Kenneth A. Jacobson, Zhan-Guo Gao, Aishe Chen, Dov Barak, Soon-Ai Kim, Kyeong Lee, Andreas Link , Bruce T. Liang, Piet Herdewijn, Serge van Calenbergh Collection Symposium Series 5 (Chemistry of Nucleic Acid Components) 267-271 (2002) |
| 25 |
Synthesis of chemoselective biotinylation agent and application Andreas Link Patent: DE 10101397 (A1) 2002-07-25 |
2001 | |
| 24 |
Aryl rings are part of the darpone pharmacophore Christiane Schultz, Andreas Link , Conrad Kunick Archiv der Pharmazie 334, 163-166 (2001) |
| 23 |
Biotin labelling of amines by polymer-assisted solution-phase synthesis Abolfasl Golisade, Claudia Herforth, Karen Wieking, Conrad Kunick , Andreas Link Bioorganic & Medicinal Chemistry Letters 11, 1783-1786 (2001) |
| 22 |
Neoceptor concept based on molecular complementarity in GPCRs: A mutant adenosine A3 receptor with selectively enhanced affinity for amine-modified nucleosides Kenneth A. Jacobson, Zhan-Guo Gao, Aishe Chen, Dov Barak, Soon-Ai Kim, Kyeong Lee, Andreas Link , Philippe van Rompaey, Serge van Calenbergh, Bruce T. Liang Journal of Medicinal Chemistry 44, 4125-4136 (2001) |
| 21 |
Wirkstoff-Entwicklung: Maßgeschneiderte Nadeln aus dem kombinatorischen Heuhaufen (Active substance development: custom-made needles from combinatoric haystacks) Andreas Link Pharmazeutische Zeitung 146, 3760-3766 (2001) |
| 20 |
Novel N6-substituted adenosines: Synthesis and biological evaluation as anti-malarial agents Abolfasl Golisade, Claudia Herforth, Jochen Wiesner, Andreas Link Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001, MEDI-M243 (2001) |
| 19 |
Biotin labeling of nucleoside derivatives via polymer assisted solution phase (PASP) synthesis Claudia Herforth, Abolfasl Golisade, Andreas Link Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001, MEDI-M311 (2001) |
2000 | |
| 18 |
Comments on the terminology for applications of temporarily attached solubility-modifying moieties in combinatorial chemistry Andreas Link Angewandte Chemie, International Edition 39, 4039-4040 (2000) |
| 17 |
Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition Rick Gussio, Daniel W. Zaharevitz, Connor F. McGrath, Nagarajan Pattabiraman, Glen E. Kellogg, Christiane Schultz, Andreas Link , Conrad Kunick , Maryse Leost, Laurent Meijer, Edward A. Sausville Anti-Cancer Drug Design 15, 53-66 (2000) |
| 16 |
Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25 Maryse Leost, Christiane Schultz, Andreas Link , Yong-Zhong Wu, Jacek Biernat, Eva-Maria Mandelkow , James A. Bibb, Gretchen L. Snyder, Paul Greengard, Daniel W. Zaharevitz, Rick Gussio, Adrian M. Senderowicz, Edward A. Sausville, Conrad Kunick , Laurent Meijer European Journal of Biochemistry 267, 5983-5994 (2000) |
| 15 |
Polymer-Assisted Solution-Phase Synthesis of 2'-Amido-2'-deoxyadenosine Derivatives Targeted at the NAD+/-Binding Sites of Parasite Enzymes Abolfasl Golisade, Jerome C. Bressi, Serge Calenbergh, Michael H. Gelb, Andreas Link Journal of Combinatorial Chemistry 2, 537-544 (2000) |
| 14 |
2'-Amino-2'-deoxy-N6-(1-naphthylmethyl)adenosine as a novel scaffold for polymer-assisted amidation protocol Abolfasl Golisade, Serge van Calenbergh, Andreas Link Tetrahedron 56, 3167-3172 (2000) |
| 13 |
Polymer-assisted Solution phase synthesis of amide libraries based on carbohydrate scaffolds Andreas Link , Abolfasl Golisade -/- Editor: Joachim Thiem 20th International Carbohydrate Symposium, Hamburg, Germany, Abstracts 147-147 (B-179) (2000) |
1999 | |
| 12 |
Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity Christiane Schultz, Andreas Link , Maryse Leost, Daniel W. Zaharevitz, Rick Gussio, Edward A. Sausville, Laurent Meijer, Conrad Kunick Journal of Medicinal Chemistry 42, 2909-2919 (1999) |
| 11 |
Antitumor pyrido[3,2-d][1]benzazepines. Synthesis and in vitro activity of thiophene analogs Andreas Link , Daniel W. Zaharevitz, Conrad Kunick Pharmazie 54, 163-166 (1999) |
| 10 |
Exploration of the effect of sterically demanding 3'-amido substitution of 3'-deoxyadenosines towards inhibition of cyclin-dependent kinase 1 Serge van Calenbergh, Andreas Link , Conrad Kunick , Piet Herdewijn Pharmazie 54, 727-729 (1999) |
| 9 |
5'-Deoxy congeners of 9-(3-amido-3-deoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine: New adenosine A1 receptor antagonists Serge van Calenbergh, Andreas Link , Shelly Fujikawa, Veerle Vanheusden, Denis De Keukeleire, Adriaan P. IJzerman, Piet Herdewijn Collection Symposium Series 2 (Chemistry of Nucleic Acid Components) 273-276 (1999) |
1998 | |
| 8 |
DNA-binding ligands from peptide libraries containing unnatural amino acids Theo Lescrinier, Chris Hendrix, Luc Kerremans, Jef Rozenski, Andreas Link , Bart Samyn, Arthur Van Aerschot, Eveline Lescrinier, Ramon Eritja, Jozef Van Beeumen, Piet Herdewijn Chemistry - A European Journal 4, 425-433 (1998) |
| 7 |
d-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity: Synthesis and Structure-Activity Relationships Andreas Link , Conrad Kunick Journal of Medicinal Chemistry 41, 1299-1305 (1998) |
| 6 |
Side reactions in solid-phase peptide synthesis caused by sulfonyl-ornithine building blocks Andreas Link , Theo Lescrinier, Luc Kerremans, Jef Rozenski, Piet Herdewijn Pharmazie 53, 200-201 (1998) |
| 5 |
Practical method for the parallel synthesis of 2'-amido-2'-deoxyadenosines Andreas Link , Serge van Calenbergh, Piet Herdewijn Tetrahedron Letters 39, 5175-5176 (1998) |
1997 | |
| 4 |
Preparation of spiro[1-benzazepine-4,1'-cyclohexane] derivatives from 1H-1-benzazepine-2,5(3H,4H)-diones and Mannich bases Andreas Link , Conrad Kunick Synthesis 297-300 (1997) |
1996 | |
| 3 |
Synthesis and in vivo testing of a potential aquaretic agent Conrad Kunick , Andreas Link , Max Hropot Pharmazie 51, 601-602 (1996) |
| 2 |
Antitumoraktive Pyrido[3,2-d]-1-benzazepine Andreas Link -/- Supervisors: Conrad Kunick , Detlef Geffken Dissertation, Hamburg (1996) |
1995 | |
| 1 |
Synthesis of pyrido[3,4-d]benzazepines Conrad Kunick , Andreas Link Journal of Heterocyclic Chemistry 32, 803-805 (1995) |