Department of Chemestry
Publications by Louisa Temme
| Search: Chemistry Dep. / all Hamburg | |
| 2025 | |
| 19 |
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases Leonie Herrmann, Christoph Brenker, Teresa Mittermair, Vesna Bojovic, Jens Münchow, W. Felix Zhu, Carla Trugge, David Fußhöller, Jan Jikeli, Louisa Temme , U. Benjamin Kaupp, Timo Strünker British Journal of Pharmacology online: 27 February 2025 (2025) |
| 18 |
Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy Joseph A. Newman, Angeline E. Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Robert te Poele, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme , Hans J. Oh, Carrow I. Wells, Zachary W. Davis-Gilbert, Paul Workman, Opher Gileadi, David H. Drewry Nature Communications 16, 1596 (2025) |
2023 | |
| 17 |
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition Maurice Dellin, Ina Rohrbeck, Purva Asrani, Julian A. Schreiber, Nadine Ritter, Frank Glorius, Bernhard Wünsch , Thomas Budde, Louisa Temme , Timo Strünker, Birgit Stallmeyer, Frank Tüttelmann, Sven G. Meuth, Marc Spehr, Johann Matschke, Andrea Steinbicker, Christos Gatsogiannis, Raphael Stoll, Nathalie Strutz-Seebohm, Guiscard Seebohm Biological Chemistry 404, 241-254 (2023) |
2022 | |
| 16 |
Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype Christopher R. M. Asquith , Louisa Temme , Michael P. East, Tuomo Laitinen, Julie Pickett, Frank E. Kwarcinski, Parvathi Sinha, Carrow I. Wells, Gary L. Johnson, Reena Zutshi, David H. Drewry ChemMedChem 17, e202200161 (10 pp) (2022) |
| 15 |
PKN3: a target in cancer metastasis Louisa Temme , Tuomo Laitinen, Christopher R. M. Asquith Nature Reviews Drug Discovery 21, 704 (1 pp) (2022) |
2021 | |
| 14 |
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes Benjamin J. Eduful, Sean N. O'Byrne, Louisa Temme , Christopher R. M. Asquith , Yi Liang, Alfredo Picado, Joseph R. Pilotte, Mohammad Anwar Hossain, Carrow I. Wells, William J. Zuercher, Carolina M. C. Catta-Preta, Priscila Zonzini Ramos, André de S. Santiago, Rafael M. Couñago, Christopher G. Langendorf, Kévin Nay, Jonathan S. Oakhill, Thomas L. Pulliam, Chenchu Lin, Dominik Awad, Timothy M. Willson, Daniel E. Frigo, John W. Scott, David H. Drewry Journal of Medicinal Chemistry 64, 10849-10877 (2021) |
| 13 |
eEF2K: an atypical kinase target for cancer Louisa Temme , Christopher R. M. Asquith Nature Reviews Drug Discovery 20, 577 (1 pp) (2021) |
2020 | |
| 12 |
Negative
allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds Louisa Temme , Elena Bechthold, Julian A. Schreiber, Sandeep Gawaskar, Dirk Schepmann, Dina Robaa, Wolfgang Sippl, Guiscard Seebohm, Bernhard Wünsch European Journal of Medicinal Chemistry 190, 112138 (2020) |
| 11 |
STK19: a new target for NRAS-driven cancer Christopher R. M. Asquith , Louisa Temme Nature Reviews Drug Discovery 19, 579 (1 pp) (2020) |
2019 | |
| 10 |
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation Louisa Temme , Frederik Börgel, Dirk Schepmann, Dina Robaa, Wolfgang Sippl, Constantin Daniliuc, Bernhard Wünsch Bioorganic & Medicinal Chemistry 27, 115146 (14 pp) (2019) |
| 9 |
Preclinical Evaluation of Benzazepine-Based PET Radioligands (R)- and (S)-11C-Me-NB1 Reveals Distinct Enantiomeric Binding Patterns and a Tightrope Walk Between GluN2B- and σ1-Receptor-Targeted PET Imaging Ahmed Haider, Adrienne Müller Herde, Stefanie D. Krämer, Jasmine Varisco, Claudia Keller, Katrin Frauenknecht, Yves P. Auberson, Louisa Temme , Dina Robaa, Wolfgang Sippl, Roger Schibli, Bernhard Wünsch , Linjing Mu, Simon M. Ametamey Journal of Nuclear Medicine August 60, 1167-1173 (2019) |
2018 | |
| 8 |
Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors Louisa Temme , Dirk Schepmann, Julian A. Schreiber, Bastian Frehland, Bernhard Wünsch ChemMedChem 13, 446-452 (2018) |
| 7 |
Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists Frederik Börgel, Marina Szermerski, Julian A. Schreiber, Louisa Temme , Nathalie Strutz-Seebohm, Kirstin Lehmkuhl, Dirk Schepmann, Simon M. Ametamey, Guiscard Seebohm, Thomas J. Schmidt, Bernhard Wünsch ChemMedChem 13, 1580-1587 (2018) |
| 6 |
Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation Louisa Temme , Bastian Frehland, Dirk Schepmann, Dina Robaa, Wolfgang Sippl, Bernhard Wünsch European Journal of Medicinal Chemistry 144, 672-681 (2018) |
2017 | |
| 5 |
Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold Sandeep Gawaskar, Louisa Temme , Julian A. Schreiber, Dirk Schepmann, Alessandro Bonifazi, Dina Robaa, Wolfgang Sippl, Nathalie Strutz-Seebohm, Guiscard Seebohm, Bernhard Wünsch ChemMedChem 12, 1212-1222 (2017) |
| 4 |
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors Sougata Dey, Louisa Temme , Julian A. Schreiber, Dirk Schepmann, Bastian Frehland, Kirstin Lehmkuhl, Nathalie Strutz-Seebohm, Guiscard Seebohm, Bernhard Wünsch European Journal of Medicinal Chemistry 138, 552-564 (2017) |
| 3 |
Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? Yoshihiro Shuto, Simone Thum, Louisa Temme , Dirk Schepmann, Masato Kitamura, Bernhard Wünsch MedChemComm 8, 975-981 (2017) |
| 2 |
Negativ allosterische Modulatoren des GluN1a/GluN2B-NMDA-Rezeptors: In silico Docking, Synthese und Entwicklung eines Testsystems zur Bestimmung der Zytoprotektion Louisa Temme -/- Supervisors: Bernhard Wünsch Dissertation, Münster (2017) |
2014 | |
| 1 |
GluN2B-Selective N-Methyl-d-aspartate (NMDA) Receptor Antagonists Derived from 3-Benzazepines: Synthesis and Pharmacological Evaluation of Benzo[7]annulen-7-amines Andre Benner, Alessandro Bonifazi, Chikako Shirataki, Louisa Temme , Dirk Schepmann, Wilma Quaglia, Osami Shoji, Yoshihito Watanabe, Constantin Daniliuc, Bernhard Wünsch ChemMedChem 9, 741-751 (2014) |