Fachbereich Chemie
Publikationen von Sebastian Wicha
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| Suche: FB Chemie / Hamburg | |
| 2024 | |
| 113 |
Model-informed precision dosing: State of the art and future perspectives Iris K. Minichmayr, Erwin Dreesen, Maddalena Centanni, Zhigang Wang, Yannick Hoffert, Lena E. Friberg, Sebastian G. Wicha Advanced Drug Delivery Reviews 215, 115421 (36 pp) (2024) |
| 112 |
Meropenem pharmacokinetics in cerebrospinal fluid: comparing intermittent and continuous infusion strategies in critically ill patients - a prospective cohort study Sebastian G. Wicha , Christina Kinast, Max Münchow, Sandra Wittova, Sebastian Greppmair, Alexandra K. Kunzelmann, Michael Zoller, Michael Paal, Michael Vogeser, Katharina Habler, Thomas Weig, Nicole Terpolilli, Suzette Heck, Konstantinos Dimitriadis, Christina Scharf, Uwe Liebchen Antimicrobial Agents and Chemotherapy 68, e00451-24 (13 pp) (2024) |
| 111 |
Reply to Gatti and Pea, "Are the pharmacokinetic data of meropenem studied in CSF of a mixed population composed of patients with cerebral infections and patients with extracerebral infections really helpful for clinicians treating CNS infections?" Sebastian G. Wicha , Christina Kinast, Max Münchow, Sandra Wittova, Sebastian Greppmair, Alexandra K. Kunzelmann, Michael Zoller, Michael Paal, Michael Vogeser, Katharina Habler, Thomas Weig, Nicole Terpolilli, Suzette Heck, Konstantinos Dimitriadis, Christina Scharf, Uwe Liebchen Antimicrobial Agents and Chemotherapy 68, e01468-24 (1 pp) (2024) |
| 110 |
Chimeric antigen receptor T-cell therapy and fludarabine: precision dosing imperatives Sebastian G. Wicha , Eva M. A. Wansing, Adrin Dadkhah, Francis A. Ayuk, Nicolaus M. Kröger, Claudia Langebrake Blood Advances 8, 797-798 (2024) |
| 109 |
Impact of Key Components of Intensified Ceftaroline Dosing on Pharmacokinetic/Pharmacodynamic Target Attainment Iris K. Minichmayr, Sebastian G. Wicha , Peter Matzneller, Charlotte Kloft, Markus Zeitlinger Clinical Pharmacokinetics 63, 121-131 (2024) |
| 108 |
Pharmacokinetic/pharmacodynamic evaluation of tigecycline dosing in a hollow fiber infection model against clinical bla-KPC producing Klebsiella Pneumoniae isolates Lisa F. Amann, Astrid Broeker, Maria Riedner , Holger Rohde , Jiabin Huang, Patrice Nordmann, Jean-Winoc Decousser, Sebastian G. Wicha Diagnostic Microbiology and Infectious Disease 108, 116153 (8 pp) (2024) |
| 107 |
Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers Hélène Thirot, David Fage, Antonia Leonhardt, Philippe Clevenbergh, Tatiana Besse-Hammer, Jean Cyr Yombi, Olivier Cornu, Caroline Briquet, Maya Hites, Frédérique Jacobs, Gert-Jan Wijnant, Sebastian G. Wicha , Frédéric Cotton, Paul M. Tulkens, Anne Spinewine, Françoise van Bambeke1 Frontiers in Pharmacology 15, 1310309 (11 pp) (2024) |
| 106 |
Predictive performance of multi-model approaches for model-informed precision dosing of piperacillin in critically ill patients Lea Marie Schatz, Sebastian Greppmair, Alexandra K. Kunzelmann, Johannes Starp, Alexander Brinkmann, Anka Roehr, Otto Frey, Stefan Hagel, Christoph Dorn, Michael Zoller, Christina Scharf, Sebastian G. Wicha , Uwe Liebchen International Journal of Antimicrobial Agents 64, 107305 (2024) |
| 105 |
Effect of albumin substitution on pharmacokinetics of piperacillin/tazobactam in patients with severe burn injury admitted to the ICU Beatrix Wulkersdorfer, Felix Bergmann, Lisa Amann, Alexandra Fochtmann-Frana, Valentin Al Jalali, Elizaveta Kurdina, Edith Lackner, Sebastian G. Wicha , Christoph Dorn, Bruno Schäfer, Gerald Ihra, Thomas Rath, Christine Radtke, Markus Zeitlinger Journal of Antimicrobial Chemotherapy 79, 262-270 (2024) |
| 104 |
Pharmacokinetics and pharmacological target attainment of standard temocillin dosing in non-critically ill patients with complicated urinary tract infections Gert-Jan Wijnant, Perrin Ngougni Pokem, Marie Coessens, Eleonora Cottone, Julian Ermtraud, Lieven Goeman, Steven Vervaeke, Sebastian G. Wicha , Françoise van Bambeke Journal of Antimicrobial Chemotherapy 79, 2204-2212 (2024) |
| 103 |
Pharmacokinetic/pharmacodynamic analysis of ceftazidime/avibactam and fosfomycin combinations in an in vitro hollow fiber infection model against multidrug-resistant Escherichia coli Niklas Krömer, Lisa F. Amann, Aneeq Farooq, Christoph Pfaffendorf, Miklas Martens, Jean-Winoc Decousser, Nicolas Grégoire, Patrice Nordmann, Sebastian G. Wicha Microbiology Spectrum 12, e03318-23 (12 pp) (2024) |
| 102 |
Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data Mohamed Maiga, Laurent Dembele, Perrine Courlet, Akash Khandelwal, Antoine Dara, Fanta Sogore, Ousmaila Diakité, Fatoumata O. Maiga, François Dao, Sekou Sissoko, Yacouba Barre, Siaka Goita, Mahamadou Diakite, Seidina A. S. Diakite, Abdoulaye A. Djimde, Claude Oeuvray, Thomas Spangenberg, Sebastian G. Wicha , Claudia Demarta-Gatsi Nature Communications 15, 7659 (11 pp) (2024) |
| 101 |
Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Dahham Alsoud, Dirk Jan A. R. Moes, Zhigang Wang, Rani Soenen, Zohra Layegh, Murray Barclay, Tomoyuki Mizuno, Iris K. Minichmayr, Ron J. Keizer, Sebastian G. Wicha , Gertjan Wolbink, Jo Lambert, Séverine Vermeire, Annick de Vries, Konstantinos Papamichael, Núria Padullés-Zamora, Erwin Dreesen Therapeutic Drug Monitoring 46, 291-308 (2024) |
2023 | |
| 100 |
Surface Grafted N-Oxides have Low-Fouling and Antibacterial Properties Nils Burmeister, Eilika Zorn, Aneeq Farooq, Lena Preuss, Christel Vollstedt, Timo Friedrich, Tomi Mantel, Nico Scharnagl, Marcus Rohnke, Mathias Ernst , Sebastian G. Wicha , Wolfgang R. Streit, Wolfgang Maison Advanced Materials Interfaces 10, 2300505 (13 pp) (2023) |
| 99 |
Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study Tjokosela Tikiso, Valentin Fuhrmann, Christina König, Dominik Jarczak, Stefanie Iwersen-Bergmann, Stefan Kluge, Sebastian G. Wicha , Jörn Grensemann Annals of Intensive Care 13, 83 (10 pp) (2023) |
| 98 |
An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, Sebastian G. Wicha , Sandrine Marchand, Nicolas Grégoire Antimicrobial Agents and Chemotherapy 67, e00301-23 (16 pp) (2023) |
| 97 |
Adaptation of a population pharmacokinetic model to inform tacrolimus therapy in heart transplant recipients Ranita Kirubakaran, David W. Uster, Stefanie Hennig, Jane E. Carland, Richard O. Day, Sebastian G. Wicha , Sophie L. Stocker British Journal of Clinical Pharmacology 89, 1162-1175 (2023) |
| 96 |
Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria Mirjam Groger, Peter Akhideno, Christine J. Kleist, Femi O. Babatunde, Osahogie Edeawe, Julia Hinzmann, ThankGod Akhigbe, Joy Nwatuzor, Gloria Eifediyi, Jonas Müller, Mette Hinrichs, Meike Pahlmann, Francisca Naana Sarpong, Christine Wagner, Anke Thielebein, Louis Aihonwalan, Till Koch, Maria Riedner , Ephraim Ogbaini-Emovon, Sylvanus Okogbenin, Stephan Günther , Sebastian G. Wicha , Michael Ramharter, Lisa Oestereich, Sophie Duraffour, Cyril Erameh Clinical Infectious Diseases 76, e841-e848 (2023) |
| 95 |
Pilot Pharmacokinetic Study in Healthy Adults Using Intravascular Microdialysis Catheters Modified for Use in Paediatric Patients to Assess Vancomycin Blood Levels Valentin Al Jalali, Martin Bauer, Michael Wölfl-Duchek, Maysa Sarhan, Sebastian G. Wicha , Stefan Poschner, Walter Jäger, Franz König, Christoph Male, Markus Zeitlinger Clinical Pharmacokinetics 62, 77-87 (2023) |
| 94 |
Zwitterionic surface modification of polyethylene via atmospheric plasma-induced polymerization of (vinylbenzyl-)sulfobetaine and evaluation of antifouling properties Nils Burmeister, Christel Vollstedt, Cathrin Kröger, Timo Friedrich, Nico Scharnagl, Marcus Rohnke, Eilika Zorn, Sebastian G. Wicha , Wolfgang R. Streit, Wolfgang Maison Colloids and Surfaces B: Biointerfaces 224, 113195 (2023) |
| 93 |
Editorial: Pharmacology of infectious diseases: world tuberculosis day 2022 Shashikant Srivastava, Johannes W. Alffenaar, Sebastian G. Wicha Frontiers in Pharmacology 14, 1233347 (3 pp) (2023) |
| 92 |
Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter Uwe Liebchen, Josef Briegel, Alexander Brinkmann, Otto Frey, Sebastian G. Wicha Intensive Care Medicine 49, 475-476 (2023) |
| 91 |
Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting Sebastian Greppmair, Alexander Brinkmann, Anka Roehr, Otto Frey, Stefan Hagel, Christoph Dorn, Amélie Marsot, Ibrahim El-Haffaf, Michael Zoller, Thomas Saller, Johannes Zander, Lea Marie Schatz, Christina Scharf, Josef Briegel, Iris K. Minichmayr, Sebastian G. Wicha , Uwe Liebchen Intensive Care Medicine 49, 966-976 (2023) |
| 90 |
Comparison of ultrafiltration and microdialysis for ceftriaxone protein-binding determination Maria Sanz-Codina, Sebastian G. Wicha , Beatrix Wulkersdorfer, Valentin Al Jalali, Wisse van Os, Matthias G. Vossen, Martin Bauer, Edith Lackner, Christoph Dorn, Markus Zeitlinger Journal of Antimicrobial Chemotherapy 78, 380-388 (2023) |
| 89 |
Evaluation of in vitro pharmacodynamic drug interactions of ceftazidime/avibactam and fosfomycin in Escherichia coli Niklas Krömer, Miklas Martens, Jean-Winoc Decousser, Nicolas Grégoire, Patrice Nordmann, Sebastian G. Wicha Journal of Antimicrobial Chemotherapy 78, 2524-2534 (2023) |
| 88 |
Drug Combination Modeling: Methods and Applications in Drug Development Rachael A. Pearson, Sebastian G. Wicha , Malek Okour Journal of Clinical Pharmacology 63, 151-165 (2023) |
| 87 |
A Model-Based Tool for Guiding Infliximab Induction Dosing to Maximize Long-term Deep Remission in Children with Inflammatory Bowel Diseases Wannee Kantasiripitak, Sebastian G. Wicha , Debby Thomas, Ilse Hoffman, Marc Ferrante, Séverine Vermeire, Karen van Hoeve, Erwin Dreesen Journal of Crohn's & Colitis 17, 896-908 (2023) |
| 86 |
Pretomanid-resistant tuberculosis Niklas Köhler, Sönke Andres, Matthias Merker, Viola Dreyer, Agnieszka John, Martin Kuhns, David Krieger, Eva Choong, Nick Verougstraete, Pia Abel zur Wiesch, Sebastian G. Wicha , Christina König, Barbara Kalsdorf, Patricia M. Sanchez Carballo, Dagmar Schaub, Jim Werngren, Thomas Schön, Charles A. Peloquin, Nicolas Schönfeld, Alain G. Verstraete, Laurent A. Decosterd, Rob E. Aarnoutse, Stefan Niemann, Florian P. Maurer, Christoph Lange Journal of Infection 86, 520-524 (2023) |
| 85 |
Operational characteristics of full random effects modelling ('frem') compared to stepwise covariate modelling ('scm') Lisa F. Amann, Sebastian G. Wicha Journal of Pharmacokinetics and Pharmacodynamics 50, 315-326 (2023) |
| 84 |
Contact-Biocide TiO2 Surfaces by Surface-Initiated Atom Transfer Radical Polymerization with Chemically Stable Phosphonate Initiators Eilika Zorn, J. Iven H. Knaack, Nils Burmeister, Nico Scharnagl, Marcus Rohnke, Sebastian G. Wicha , Wolfgang Maison Langmuir 39, 11063-11072 (2023) |
| 83 |
Low-Fouling and Antibacterial Polymer Brushes via Surface-Initiated Polymerization of a Mixed Zwitterionic and Cationic Monomer Nils Burmeister, Eilika Zorn, Lena Preuss, Donovan Timm, Nico Scharnagl, Marcus Rohnke, Sebastian G. Wicha , Wolfgang R. Streit, Wolfgang Maison Langmuir 39, 17959-17971 (2023) |
| 82 |
A Single-Run HPLC-MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis Niklas Köhler, Hande Karakoese, Hans-Peter Grobbel, Doris Hillemann, Sönke Andres, Christina König, Barbara Kalsdorf, Thomas Theo Brehm, Laura Böttcher, Inna Friesen, Harald Hoffmann, Drazen Strelec, Dagmar Schaub, Charles A. Peloquin, Stefan Schmiedel, Laurent A. Decosterd, Eva Choong, Sebastian G. Wicha , Rob E. Aarnoutse, Christoph Lange, Patricia M. Sanchez Carballo Pharmaceutics 15, 2543 (23 pp) (2023) |
2022 | |
| 81 |
Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction Christine J. Kleist, Chi-Un Choe, Dorothee Atzler, Mirjam Schönhoff, Rainer Böger, Edzard Schwedhelm, Sebastian G. Wicha Amino Acids 54, 889-896 (2022) |
| 80 |
Tigecycline Dosing Strategies in Critically Ill Liver-Impaired Patients Lisa F. Amann, Rawan Alraish, Astrid Broeker, Magnus Kaffarnik, Sebastian G. Wicha Antibiotics 11, 479 (12 pp) (2022) |
| 79 |
New in vitro interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations Sebastian G. Wicha , Annabelle Walz, Mohammed H. Cherkaoui-Rbati, Nils Bundgaard, Karsten Kuritz, Christin Gumpp, Nathalie Gobeau, Jörg Möhrle, Matthias Rottmann, Claudia Demarta-Gatsi Antimicrobial Agents and Chemotherapy 66, 00556-22 (2022) |
| 78 |
Population pharmacokinetics and target attainment analysis of linezolid in multidrug-resistant tuberculosis patients Anna K. Tietjen, Niklas Krömer, Dario Cattaneo, Sara Baldelli, Sebastian G. Wicha British Journal of Clinical Pharmacology 88, 1835-1844 (2022) |
| 77 |
A dosing nomograph for cerebrospinal fluid penetration of meropenem applied by continuous infusion in patients with nosocomial ventriculitis Christina König, Jörn Grensemann, Patrick Czorlich, Eckhard Schlemm, Stefan Kluge, Sebastian G. Wicha Clinical Microbiology and Infection 28, 1022.e9-1022.e16 (2022) |
| 76 |
Pharmacokinetics and Pharmacodynamics of Tedizolid Khalid Iqbal, Aliki Milioudi, Sebastian G. Wicha Clinical Pharmacokinetics 61, 489-503 (2022) |
| 75 |
Optimized sampling to estimate vancomycin drug exposure: Comparison of pharmacometric and equation-based approaches in a simulation-estimation study David W. Uster, Sebastian G. Wicha CPT: Pharmacometrics & Systems Pharmacology 11, 711-720 (2022) |
| 74 |
Multi-model averaging improves the performance of model-guided infliximab dosing in patients with inflammatory bowel diseases Wannee Kantasiripitak, An Outtier, Sebastian G. Wicha , Alexander Kensert, Zhigang Wang, João Sabino, Séverine Vermeire, Debby Thomas, Marc Ferrante, Erwin Dreesen CPT: Pharmacometrics & Systems Pharmacology 11, 1045-1059 (2022) |
| 73 |
Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: an evaluation of in vitro, in vivo methodologies and human studies Jan-Willem C. Alffenaar, Jurriaan E. M. de Steenwinkel, Andreas H. Diacon, Ulrika S. H. Simonsson, Shashikant Srivastava, Sebastian G. Wicha Frontiers in Pharmacology 13, 1063453 (13 pp) (2022) |
| 72 |
Population pharmacokinetics and toxicodynamics of continuously infused linezolid in critically ill patients Sebastian G. Wicha , Andrea Mair, Ute Chiriac, Otto R. Frey, Thomas Fuchs, Max Gaasch, Stefan Hagel. Daniel C. Richter, Jason A. Roberts, Anka C. Röhr, Markus A. Weigand, Alexander Brinkmann International Journal of Antimicrobial Agents 59, 106572 (2022) |
| 71 |
Model-informed precision dosing of vancomycin via continuous infusion: a clinical fit-for-purpose evaluation of published PK models Astrid Heus, David W. Uster, Veerle Grootaert, Nele Vermeulen, Annemie Somers, Diana Huis in't Veld, Sebastian G. Wicha , Pieter A. de Cock International Journal of Antimicrobial Agents 59, 106579 (2022) |
| 70 |
A pharmacokinetic-pharmacodynamic (PKPD) model-based analysis of tedizolid against enterococci using the hollow-fibre infection model Khalid Iqbal, H. Rohde, J. Huang, T. Tikiso, Lisa F. Amann, Markus Zeitlinger, Sebastian G. Wicha Journal of Antimicrobial Chemotherapy 77, 2470-2478 (2022) |
| 69 |
Understanding the suitability of established antibiotics for oral inhalation from a pharmacokinetic perspective: an integrated model-based investigation based on rifampicin, ciprofloxacin and tigecycline in vivo data Anneke Himstedt, Clemens Braun, Sebastian G. Wicha , Jens Markus Borghardt Journal of Antimicrobial Chemotherapy 77, 2922-2932 (2022) |
| 68 |
Inferring pulmonary exposure based on clinical PK data: accuracy and precision of model-based deconvolution methods Anneke Himstedt, Jens Markus Borghardt, Sebastian G. Wicha Journal of Pharmacokinetics and Pharmacodynamics 49, 135-149 (2022) |
| 67 |
Research priorities towards precision antibiotic therapy to improve patient care Zackery P. Bulman, Sebastian G. Wicha , Elisabet I. Nielsen, Justin R. Lenhard, Roger L. Nation, Ursula Theuretzbacher, Hartmut Derendorf, Thomas Tängdén, Markus Zeitlinger, Cornelia B. Landersdorfer, Jürgen B. Bulitta, Lena E. Friberg, Jian Li, Brian T. Tsuji Lancet. Microbe 3, e795-e802 (2022) |
| 66 |
A Machine Learning Approach to Predict Interdose Vancomycin Exposure Mehdi Bououda, David W. Uster, Egor Sidorov, Marc Labriffe, Pierre Marquet, Sebastian G. Wicha , Jean-Baptiste Woillard Pharmaceutical Research 39, 721-731 (2022) |
| 65 |
Optimized Rhombic Experimental Dynamic Checkerboard Designs to Elucidate Pharmacodynamic Drug Interactions of Antibiotics Niklas Krömer, Romain Aubry, William Couet, Nicolas Grégoire, Sebastian G. Wicha Pharmaceutical Research 39, 3267-3277 (2022) |
| 64 |
Ciprofloxacin in Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO): A Population Pharmacokinetic Study Dzenefa Alihodzic, Sebastian G. Wicha , Otto R. Frey, Christina König, Michael Baehr, Dominik Jarczak, Stefan Kluge, Claudia Langebrake Pharmaceutics 14, 965 (15 pp) (2022) |
| 63 |
Population Pharmacokinetics of Busulfan and Its Metabolite Sulfolane in Patients with Myelofibrosis Undergoing Hematopoietic Stem Cell Transplantation Adrin Dadkhah, Sebastian G. Wicha , Nicolaus Kröger , Alexander Müller, Christoph Pfaffendorf, Maria Riedner , Anita Badbaran, Boris Fehse, Claudia Langebrake Pharmaceutics 14, 1145 (13 pp) (2022) |
| 62 |
Systematic Comparison of Hospital-Wide Standard and Model-Based Therapeutic Drug Monitoring of Vancomycin in Adults Heleen Gastmans, Erwin Dreesen, Sebastian G. Wicha , Nada Dia, Ellen Spreuwers, Annabel Dompas, Karel Allegaert, Stefanie Desmet, Katrien Lagrou, Willy E. Peetermans, Yves Debaveye, Isabel Spriet, Matthias Gijsen Pharmaceutics 14, 1459 (13 pp) (2022) |
| 61 |
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G. Wicha , Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M. Svensson, Michael P. Menden, Ulrika S. H. Simonsson Pharmaceutics 14, 1530 (29 pp) (2022) |
| 60 |
Liver function, quantified by the LiMAx test, as a predictor for the clinical outcome of critically ill patients treated with linezolid Rawana Alraish, Sebastian G. Wicha , Otto R. Frey, Anka Roehr, Johanna Pratschke, Martina Stockmann, Tiloa Wuensch, Magnusa Kaffarnik Technology and Health Care 30, 309-321 (2022) |
| 59 |
Dosing for Personalized Prophylaxis in Hemophilia A Highly Varies on the Underlying Population Pharmacokinetic Models David W. Uster, Pratima Chowdary, Anne Riddell, Cecilia Garcia, Elsa Aradom, Molly Musarara, Sebastian G. Wicha Therapeutic Drug Monitoring 44, 665-673 (2022) |
2021 | |
| 58 |
Towards precision dosing of vancomycin in critically ill patients: an evaluation of the predictive performance of pharmacometric models in ICU patients Christopher B. Cunio, David W. Uster, Jane E. Carland, Hergen Buscher, Zhixen Liu, Jonathan Brett, Maurizio Stefani, Graham R. D. Jones, Richard O. Day, Sebastian G. Wicha , Sophie L. Stocker Clinical Microbiology and Infection 27, 783.E7-783.E14 (2021) |
| 57 |
A Model Averaging/Selection Approach Improves the Predictive Performance of Model-Informed Precision Dosing: Vancomycin as a Case Study David W. Uster, Sophie L. Stocker, Jane E. Carland, Jonathan Brett, Deborah J. E. Marriott, Richard O. Day, Sebastian G. Wicha Clinical Pharmacology & Therapeutics 109, 175-183 (2021) |
| 56 |
From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics Sebastian G. Wicha , Anne-Grete Märtson, Elisabet I. Nielsen, Birgit C. P. Koch, Lena E. Friberg, Jan-Willem C. Alffenaar, Iris K. Minichmayr Clinical Pharmacology & Therapeutics 109, 928-941 (2021) |
| 55 |
Stability studies with tigecycline in bacterial growth medium and impact of stabilizing agents Lisa F. Amann, Emilia Ruda Vicente, Mareike Rathke, Astrid Broeker, Maria Riedner , Sebastian G. Wicha European Journal of Clinical Microbiology & Infectious Diseases 40, 215-218 (2021) |
| 54 |
Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data Gudrun Würthwein, Claudia Lanvers-Kaminsky, Christian Siebel, Joachim Gerß, Anja Möricke, Martin Zimmermann, Jan Stary, Petr Smisek, Martin Schrappe, Carmelo Rizzari, Massimo Zucchetti, Georg Hempel, Sebastian G. Wicha , Joachim Boos European Journal of Drug Metabolism and Pharmacokinetics 46, 289-300 (2021) |
| 53 |
In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model Matthias G. Vossen, S. Pferschy, C. Milacek, M. Haidinger, Mario Karolyi, Zoltan Vass, Heinz Burgmann, Alexandra Maier-Salamon, Sebastian G. Wicha , Walter Jäger, Markus Zeitlinger, Thomas Stimpf, Thomas Wittek, Florian Thalhammer Frontiers in Pharmacology 12, 702455 (8 pp) (2021) |
| 52 |
Comparison of two empirical prolonged infusion dosing regimens for meropenem in patients with septic shock: A two-center pilot study Albrecht Eisert, Christian Lanckohr, Janina Freyd, Otto Freye, Sebastian G. Wicha , Dagmar Horn, Bjoern Ellger, Tobias Schürholz, Gernot Marx, Tim-Philipp Simon International Journal of Antimicrobial Agents 57, 106289 (8 pp) (2021) |
| 51 |
Assessment of cefepime toxico-dynamics: comprehensive examination of pharmacokinetic?/pharmacodynamic targets for cefepime-induced neurotoxicity and evaluation of current dosing guidelines Cindy Lau, Deborah Marriott, Hayley B. Schultz, Michael Gould, David Andresen, Sebastian G. Wicha , Jan-Willem Alffenaar, Jonathan Penm, Stephanie E. Reuter International Journal of Antimicrobial Agents 58, 106443 (2021) |
| 50 |
Assessment of cefepime toxicodynamics: comprehensive examination of pharmacokinetic/pharmacodynamic targets for cefepime-induced neurotoxicity and evaluation of current dosing guidelines Cindy Lau, Deborah Marriott, Hayley B. Schultz, Michael Gould, David Andresen, Sebastian G. Wicha , Jan-Willem Alffenaar, Jonathan Penm, Stephanie E. Reuter International Journal of Antimicrobial Agents 58, 106443 (2021) |
| 49 |
Protein binding of clindamycin in vivo by means of intravascular microdialysis in healthy volunteers Beatrix Wulkersdorfer, Sebastian G. Wicha , Elizaveta Kurdina, Stephan F. Carrion Carrera, Peter Matzneller, Valentin Al Jalali, Matthias G. Vossen, Sonja Riesenhuber, Edith Lackner, Christoph Dorn, Markus Zeitlinger Journal of Antimicrobial Chemotherapy 76, 2106-2113 (2021) |
| 48 |
Voriconazole Pharmacokinetics Are Not Altered in Critically Ill Patients with Acute-on-Chronic Liver Failure and Continuous Renal Replacement Therapy: An Observational Study Jörn Grensemann, Christoph Pfaffendorf, Sebastian G. Wicha , Christina König, Kevin Roedl, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Valentin Fuhrmann Microorganisms 9, 2087 (13 pp) (2021) |
| 47 |
Evaluation of the Robustness of Therapeutic Drug Monitoring Coupled with Bayesian Forecasting of Busulfan with Regard to Inaccurate Documentation Adrin Dadkhah, Dzenefa Alihodzic, Astrid Broeker, Nicolaus Kröger , Claudia Langebrake, Sebastian G. Wicha Pharmaceutical Research 38, 1721-1729 (2021) |
| 46 |
A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice Sebastian Franck, Robin Michelet, Fiordiligie Casilag, Jean-Claude Sirard, Sebastian G. Wicha , Charlotte Kloft Pharmaceutics 13, 469 (11 pp) (2021) |
| 45 |
The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia Robin Michelet, Moreno Ursino, Sandrine Boulet, Sebastian Franck, Fiordiligie Casilag, Mara Baldry, Jens Rolff, Madelé van Dyk, Sebastian G. Wicha , Jean-Claude Sirard, Emmanuelle Comets, Sarah Zohar, Charlotte Kloft Pharmaceutics 13, 601 (12 pp) (2021) |
| 44 |
Determination of Tedizolid in Bacterial Growth Medium Mueller-Hinton Broth by High-Performance Liquid Chromatography and Its Application to an In Vitro Study in the Hollow-Fiber Infection Model Khalid Iqbal, Aliki Milioudi, Elena Haro Martinez, Sebastian G. Wicha Separations 8, 141 (9 pp) (2021) |
2020 | |
| 43 |
Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx) Rawan Alraish, Sebastian G. Wicha , Otto R. Frey, Anka C. Röhr, Johann Pratschke, Martin Stockmann, Tilo Wuensch, Magnus Kaffarnik Annals of Intensive Care 10, 106 (9 pp) (2020) |
| 42 |
Total Synthesis of Anti-MRSA Active Diorcinols and Analogues Gordon Jacob Boehlich, Jessica de Vries, Olivia Geismar, Mirja Gudzuhn, Wolfgang R. Streit, Sebastian G. Wicha , Nina Schützenmeister Chemistry - A European Journal 26, 9846-9850 (2020) Reprint: Young Chemists (2020) |
| 41 |
How to design a study to evaluate therapeutic drug monitoring in infectious diseases? Anne-Grete Märtson, Marieke G. G. Sturkenboom, Jana Stojanova, Dario Cattaneo, William Hope, Debbie Marriott, Asad E. Patanwala, Charles A. Peloquin, Sebastian G. Wicha , Tjip S. van der Werf, Thomas Tängdén, Jason A. Roberts, Michael N. Neely, Jan-Willem C. Alffenaar Clinical Microbiology and Infection 26, 1008-1016 (2020) |
| 40 |
A pharmacometric approach to define target site-specific breakpoints for bacterial killing and resistance suppression integrating microdialysis, time-kill curves and heteroresistance data: A case study with moxifloxacin Khalid Iqbal, Astrid Broeker, Hartmut Nowak, Tim Rahmel, Alina Nussbaumer-Pröll, Zoe Österreicher, Markus Zeitlinger, Sebastian G. Wicha Clinical Microbiology and Infection 26, 1255.e1-1255.e8 (2020) |
| 39 |
Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development Budi O. Susanto, Sebastian G. Wicha , Yanmin Hu, Anthony R. M. Coates, Ulrika S. H. Simonsson Clinical Pharmacology & Therapeutics 108, 274-286 (2020) |
| 38 |
Contact-active antibacterial polyethylene foils via atmospheric air plasma induced polymerisation of quaternary ammonium salts Serge Kliewer, Sebastian G. Wicha , Astrid Broeker, Tim Naundorf, Tugba Catmadim, Eva Katharina Oellingrath, Marcus Rohnke, Wolfgang R. Streit, Christel Vollstedt, Helmut Kipphardt, Wolfgang Maison Colloids and Surfaces, B: Biointerfaces 186, 110679 (7 pp) (2020) |
| 37 |
Therapeutisches Drug Monitoring von Antiinfektiva bei Intensivpatienten - für welche Arzneistoffe und wie? (Therapeutic drug monitoring of antiinfectives in intensive care unit patients - what's new? Christina König, Stefan Kluge, Sebastian G. Wicha Deutsche Medizinische Wochenschrift 145, 1764-1769 (2020) |
| 36 |
Impact of Inaccurate Documentation of Sampling and Infusion Time in Model-Informed Precision Dosing Dzenefa Alihodzic, Astrid Broeker, Michael Baehr, Stefan Kluge, Claudia Langebrake, Sebastian G. Wicha Frontiers in Pharmacology 11, 172 (12 pp) (2020) |
| 35 |
Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review Hannah Yejin Kim, Anne-Grete Märtson, Erwin Dreesen, Isabel Spriet, Sebastian G. Wicha , Andrew J. McLachlan, Jan-Willem C. Alffenaar Frontiers in Pharmacology 11, 894 (15 pp) (2020) |
| 34 |
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper Mohd H. Abdul-Aziz, Jan-Willem C. Alffenaar, Matteo Bassetti, Hendrik Bracht, George Dimopoulos, Deborah Marriott, Michael N. Neely, Jose-Artur Paiva, Federico Pea, Fredrik Sjovall, Jean F. Timsit, Andrew A. Udy, Sebastian G. Wicha , Markus Zeitlinger, Jan J. De Waele, Jason A. Roberts Intensive Care Medicine 46, 1127-1153 (2020) |
| 33 |
Mobile Health Apps for Improvement of Tuberculosis Treatment: Descriptive Review Lina Keutzer, Sebastian G. Wicha , Ulrika S. H. Simonsson JMIR mHealth and uHealth 8 (4) e17246 (2020) |
| 32 |
Pharmacokinetics of trimethoprim/sulfametrole in critically ill patients on continuous renal replacement therapy René Welte, Rudolph Beyer, Johannes Hotter, Astrid Broeker, Sebastian G. Wicha , Tiziana Gasperetti, Paul Ranke, Marc-Michael Zaruba, Ingo Lorenz, Stephan Eschertzhuber, Mathias Ströhle, Rosa Bellmann-Weiler, Michael Joannidis, Romuald Bellmann Journal of Antimicrobial Chemotherapy 75, 1237-1241 (2020) |
| 31 |
Assessing parameter uncertainty in small-n pharmacometric analyses: value of the log-likelihood profiling-based sampling importance resampling (LLP-SIR) technique Astrid Broeker, Sebastian G. Wicha Journal of Pharmacokinetics and Pharmacodynamics 47, 219-228 (2020) |
| 30 |
An Integrated Dialysis Pharmacometric (IDP) Model to Evaluate the Pharmacokinetics in Patients Undergoing Renal Replacement Therapy Astrid Broeker, Matthias G. Vossen, Florian Thalhammer, Steven C. Wallis, Jeffrey Lipman, Jason A. Roberts, Sebastian G. Wicha Pharmaceutical Research 37, 96 (15 pp) (2020) |
| 29 |
Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention-A Combined In Vivo/In Silico Approach Based on Four Model Drugs Anneke Himstedt, Clemens Braun, Sebastian G. Wicha , Jens Markus Borghardt Pharmaceutics 12, 408 (20 pp) (2020) |
2019 | |
| 28 |
Towards precision dosing of vancomycin: A systematic evaluation of pharmacometric models for Bayesian forecasting Astrid Broeker, Madeleine Nardecchia, Kenneth P. Klinker, Hartmut Derendorf, Richard O. Day, Deborah J. Marriott, Jane E. Carland, Sophie L. Stocker, Sebastian G. Wicha Clinical Microbiology and Infection 25, 1286 (7 pp) (2019) |
| 27 |
Is Moxifloxacin a Treatment Option for Pancreatic Infections? A Pharmacometric Analysis of Serum and Pancreatic Juice Sebastian G. Wicha , Ralf G. Mundkowski, Andrea Klock, Ulrich T. Hopt, Bernd Drewelow, Charlotte Kloft, Ulrich F. Wellner, Tobias Keck, Uwe A. Wittel Journal of Clinical Pharmacology 59, 1405-1414 (2019) |
| 26 |
After standard dosage of piperacillin plasma concentrations of drug are subtherapeutic in burn patients Katharina Olbrisch, Tobias Kisch, Julia Thern, Evelyn Kramme, Jan Rupp, Tobias Graf, Sebastian G. Wicha , Peter Mailänder, Walter Raasch Naunyn-Schmiedeberg's Archives of Pharmacology 392, 229-241 (2019) |
| 25 |
A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume Sebastian Franck, Tania Fuhrmann-Selter, Jan F. Joseph, Robin Michelet, Fiordiligie Casilag, Jean-Claude Sirard, Sebastian G. Wicha , Charlotte Kloft Talanta 201, 253-258 (2019) |
2018 | |
| 24 |
Comparisons of Analysis Methods for Assessment of Pharmacodynamic Interactions Including Design Recommendations Chunli Chen, Sebastian G. Wicha , Rikard Nordgren, Ulrika S. H. Simonsson AAPS Journal 20, 77 (12 pp) (2018) |
| 23 |
Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients Lena Klopp-Schulze, Markus Joerger, Sebastian G. Wicha , Rob ter Heine, Chantal Csajka, Zinnia P. Parra-Guillen, Charlotte Kloft Clinical Pharmacokinetics 57, 229-242 (2018) |
| 22 |
Individualised dosing algorithms and therapeutic monitoring for antiepileptic drugs Sven C. van Dijkman, Sebastian G. Wicha , Meindert Danhof, Oscar E. Della Pasqua Clinical Pharmacology & Therapeutics 103, 663-673 (2018) |
| 21 |
Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin Sebastian G. Wicha , Oskar Clewe, Robin J. Svensson, Stephen H. Gillespie, Yanmin Hu, Anthony R. M. Coates, Ulrika S. H. Simonsson Clinical Pharmacology & Therapeutics 104, 1208-1218 (2018) |
| 20 |
Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study Astrid Broeker, Sebastian G. Wicha , Christoph Dorn, Alexander Kratzer, Michael Schleibinger, Frieder Kees, Alexandra Heininger, M. G. Kees, Helene Häberle Critical Care 22, 341 (7 pp) (2018) |
| 19 |
Quantitative systems pharmacology in model-informed drug development and therapeutic use Sebastian G. Wicha , Charlotte Kloft Current Opinion in Systems Biology 10, 19-25 (2018) |
| 18 |
A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations Oskar Clewe, Sebastian G. Wicha , Corné P. de Vogel, Jurriaan E. M. de Steenwinkel, Ulrika S. H. Simonsson Journal of Antimicrobial Chemotherapy 73, 437-447 (2018) |
2017 | |
| 17 |
Translational pharmacometric evaluation of typical antibiotic broad-spectrum combination therapies against Staphylococcus aureus exploiting in vitro information Sebastian G. Wicha , Wilhelm Huisinga, Charlotte Kloft CPT: Pharmacometrics & Systems Pharmacology 6, 512-522 (2017) |
| 16 |
Assessing Pharmacodynamic Interactions in Mice using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models Chunli Chen, Sebastian G. Wicha , Gerjo J. de Knegt, Fatima Ortega, Laura Alameda, Veronica Sousa, Jurriaan E. M. de Steenwinkel, Ulrika S. H. Simonsson CPT: Pharmacometrics & Systems Pharmacology 6, 787-797 (2017) |
| 15 |
Linezolid in liver failure: exploring the value of the maximal liver function capacity (LiMAx) test in a pharmacokinetic pilot study Sebastian G. Wicha , Otto R. Frey, Anka C. Röhr, Johann Pratschke, Martin Stockmann, Rawan Alraish, Tilo Wuensch, Magnus Kaffarnik International Journal of Antimicrobial Agents 50, 557-563 (2017) |
| 14 |
Making use of modeling and simulations: Towards individualized tamoxifen therapy in breast cancer Lena Klopp-Schulze, Markus Joerger, Sebastian G. Wicha , Zinnia P. Parra-Guillen, Charlotte Kloft International Journal of Clinical Pharmacology and Therapeutics 55, 690-691 (2017) |
| 13 |
A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions Sebastian G. Wicha , Chunli Chen, Oskar Clewe, Ulrika S. H. Simonsson Nature Communications 8, 2129 (11 pp) (2017) |
2016 | |
| 12 |
Simultaneous determination and stability studies of linezolid, meropenem and vancomycin in bacterial growth medium by high-performance liquid chromatography Sebastian G. Wicha , Charlotte Kloft Journal of Chromatography, B 1028, 242-248 (2016) |
| 11 |
Population pharmacokinetics of meropenem during continuous infusion in surgical ICU patients Martin G. Kees, Iris K. Minichmayr, Stefan Moritz, Stefanie Beck, Sebastian G. Wicha , Frieder Kees, Charlotte Kloft, Thomas Steinke Journal of Clinical Pharmacology 56, 307-315 (2016) |
| 10 |
Pharmakometrie-basiertes TDM mit TDMx Sebastian G. Wicha , Anka C. Röhr, Otto R. Frey, Alexander Brinkmann, Charlotte Kloft Krankenhauspharmazie 37, 212-221 (2016) |
| 9 |
Variable Linezolid Exposure in Intensive Care Unit Patients-Possible Role of Drug-Drug Interactions Christoph Töpper, Catherine L. Steinbach, Christoph Dorn, Alexander Kratzer, Sebastian G. Wicha , Michael Schleibinger, Uwe Liebchen, Frieder Kees, Bernd Salzberger, Martin G. Kees Therapeutic Drug Monitoring 38, 573-578 (2016) |
2015 | |
| 8 |
Concentration-response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium Christian Scheerans, Sebastian G. Wicha , Julia Michael, Hartmut Derendorf, Charlotte Kloft International Journal of Antimicrobial Agents 45, 54-60 (2015) |
| 7 |
TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine Sebastian G. Wicha , Martin G. Kees, Alexander Solms, Iris K. Minichmayr, Alexander Kratzer, Charlotte Kloft International Journal of Antimicrobial Agents 45, 442-444 (2015) |
| 6 |
Population pharmacokinetics and target attainment analysis of moxifloxacin in patients with diabetic foot infections Sebastian G. Wicha , Thomas Haak, Karl Zink, Frieder Kees, Charlotte Kloft, Martin G. Kees Journal of Clinical Pharmacology 55, 639-646 (2015) |
| 5 |
Pharmacodynamic and response surface analysis of linezolid or vancomycin combined with meropenem against Staphylococcus aureus Sebastian G. Wicha , Martin G. Kees, Janin Kuss, Charlotte Kloft Pharmaceutical Research 32, 2410-2418 (2015) |
| 4 |
Integrated in vitro and in silico studies for optimisation of broad-spectrum antibiotic combination therapy Sebastian G. Wicha (= Sebastian Georg Wicha) -/- Betreuer: Charlotte Kloft Dissertation, FU Berlin (2015) |
2014 | |
| 3 |
Pharmacokinetics and pharmacodynamics of antibiotic therapy Stefanie Beck, Sebastian G. Wicha , Charlotte Kloft, Martin G. Kees Anaesthesist 63, 775-782 (2014) |
| 2 |
Unbound fraction of ertapenem in intensive care unit patients Uwe Liebchen, Alexander Kratzer, Sebastian G. Wicha , Frieder Kees, Charlotte Kloft, Martin G. Kees Journal of Antimicrobial Chemotherapy 69, 3108-3111 (2014) |
| 1 |
Unbound fraction of vancomycin in intensive care unit patients Martin G. Kees, Sebastian G. Wicha , Astrid Seefeld, Frieder Kees, Charlotte Kloft Journal of Clinical Pharmacology 54, 318-323 (2014) |