Fachbereich Chemie
Kurzbiographie und Publikationen von Jörg Andrä
Kurzbiographie
1965 | geboren in Castrop-Rauxel |
1993-1997 | Wissenschaftlicher Mitarbeiter im BMBF-Projekt: "Molekularer Mechanismus der cytolytischen Reaktion von Entamoeba histolytica" |
1996 | Promotion bei Matthias Leippe (Bernhard-Nocht-Institut) in Hamburg |
1997-2002 | Wissenschaftlicher Assistent (C1) am Fachbereich Chemie, Abteilung für Biochemie und Molekularbiologie, Universität Hamburg |
2002-2005 | Wissenschaftlicher Mitarbeiter in der Laborgruppe Biophysik am Forschungszentrum Borstel im EU-Projekt ANEPID (Antimicrobial Endotoxin Neutralising Peptides to Combat Infectious Diseases, Klaus Brandenburg) |
2004 | Gastaufenthalt bei Satoshi Fukuoka am Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science and Technology, AIST-Shikoku, Takamatsu, Japan |
2005-2009 | Wissenschaftlicher Mitarbeiter in der Laborgruppe Biophysik am Forschungszentrum Borstel im SFB 617: Molekulare Mechanismen der epithelialen Abwehr (Thomas Gutsmann) |
2005 | Habilitation im Fachbereich Chemie der Universität Hamburg für das Fach Biochemie |
2006 | Verleihung der Lehrbefugnis (venia legendi) als Privatdozent an der Universität Hamburg für das Fach Biochemie |
2010-2011 | Projektleiter am Forschungszentrum Borstel |
2012- | W2-Professur für Organische Chemie und Biochemie an der Hochschule für Angewandte Wissenschaften (HAW) Hamburg |
Weitere Informationen
- Berichte in den Nachrichten aus der Chemie (GdCh)
- Homepage an der HAW
- Eintrag im Hamburger Professorinnen- und Professorenkatalog
Alternative Namensschreibungen
- Jörg Peter Andrä
- Jörg Andrä
Publikationen
(nur bis zum Ende der Universität Hamburg Zeit, bis 2011)
.
Suche: FB Chemie / Hamburg | |
2011 | |
67 |
Structural features governing the activity of lactoferricin derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo Susana Sánchez-Gómez, Bostjan Japelj, Roman Jerala, Ignacio Moriyón, Mirian Fernández Alonso, José Leiva, Sylvie E. Blondelle, Jörg Andrä , Klaus Brandenburg , Karl Lohner, Guillermo Martinez de Tejada Antimicrobial Agents and Chemotherapy 55, 218-228 (2011) |
66 |
Peptide-based treatment of sepsis Klaus Brandenburg , Jörg Andrä , Patrick Garidel , Thomas Gutsmann Applied Microbiology and Biotechnology 90, 799-808 (2011) |
65 |
Online monitoring of metabolism and morphology of peptide-treated neuroblastoma cancer cells and keratinocytes Sabine Drechsler, Jörg Andrä Journal of Bioenergetics and Biomembranes 43, 275-285 (2011) |
64 |
Multiple Peptide Resistance Factor (MprF)-mediated Resistance of Staphylococcus aureus against Antimicrobial Peptides Coincides with a Modulated Peptide Interaction with Artificial Membranes Comprising Lysyl-Phosphatidylglycerol Jörg Andrä , Torsten Goldmann, Christoph M. Ernst, Andreas Peschel, Thomas Gutsmann Journal of Biological Chemistry 286, 18692-18700 (2011) |
63 |
Studies on Lactoferricin-derived Escherichia coli Membrane-active Peptides Reveal Differences in the Mechanism of N-Acylated Versus Nonacylated Peptides Dagmar Zweytick, Günter Deutsch, Jörg Andrä , Sylvie E. Blondelle, Ekkehard Vollmer, Roman Jerala, Karl Lohner Journal of Biological Chemistry 286, 21266-21276 (2011) |
2010 | |
62 |
Effective antimicrobial and anti-endotoxin activity of cationic peptides based on lactoferricin: a biophysical and microbiological study Klaus Brandenburg , Jörg Howe, Susana Sánchez-Gómez, Patrick Garidel , Manfred Rössle, Jörg Andrä , Roman Jerala, Dagmar Zweytick, Karl Lohner, Michael Rappolt, Sylvie E. Blondelle, Ignacio Moriyón, Guillermo Martinez de Tejada Anti-Infective Agents in Medicinal Chemistry 9, 9-22 (2010) |
61 |
Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis Malte U. Hammer, Annemarie Brauser, Claudia Olak, Gerald Brezesinski, Torsten Goldmann, Thomas Gutsmann , Jörg Andrä Biochemical Journal 427, 477-488 (2010) |
60 |
Molecular
basis for endotoxin neutralization by amphipathic peptides derived from the α-helical cationic core-region of NK-lysin Klaus Brandenburg , Patrick Garidel , Satoshi Fukuoka, Jörg Howe, Michel H. J. Koch, Thomas Gutsmann , Jörg Andrä Biophysical Chemistry 150, 80-87 (2010) |
59 |
Conformational Properties of Arenicins: From the Bulk to the Air-Water Interface Oksana G. Travkova, Jörg Andrä , Helmuth Möhwald, Gerald Brezesinski ChemPhysChem 11, 3262-3268 (2010) |
58 |
Physicochemical and biological characterization of anti-endotoxin peptides and their influence on lipid properties Ina Kowalski, Yani Kaconis, Jörg Andrä , Iosu Razquin-Olazaran, Thomas Gutsmann , Guillermo Martinez de Tejada, Klaus Brandenburg Protein & Peptide Letters 17, 1328-1333 (2010) |
57 |
Langmuir monolayers at the liquid-air interface: a useful tool to study the interaction of membrane-active peptides with phospholipids Claudia Olak, Jörg Andrä , Gerald Brezesinski -/- Herausgeber: Miguel A. R. B. Castanho IUL Biotechnology Series 9 (Membrane-Active Peptides) 81-112 (2010), ISBN 978-0-9720774-5-3 , Verlag: International University Line, La Jolla |
2009 | |
56 |
Interaction of melittin with phospholipid- and lipopolysaccharide-containing model membranes Maria Hanulova, Jörg Andrä , Patrick Garidel , Claudia Olak, Jörg Howe, Sergio S. Funari, Thomas Gutsmann , Klaus Brandenburg Anti-Infective Agents in Medicinal Chemistry 8, 17-27 (2009) |
55 |
Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes Jörg Andrä , Malte U. Hammer, Joachim Grötzinger, Igor Jakovkin, Buko Lindner, Ekkehard Vollmer, Henning Fedders, Matthias Leippe, Thomas Gutsmann Biological Chemistry 390, 337-349 (2009) |
54 |
Interactions between lipid A and serum proteins Jörg Andrä , Thomas Gutsmann , Mareike Müller, Andra B. Schromm Advances in Experimental Medicine and Biology 667 (Lipid A in Cancer Therapy) 39-51 (2009) |
53 |
Pathogens in sepsis: gram-negative bacterial PAMPS and PRRs Andra B. Schromm, Christian Alexander, Thomas Gutsmann , Jörg Andrä , Cordula Stamme Sepsis and Non-infectious Systemic Inflammation 79-108 (2009), ISBN 978-3-527-31935-0 , Verlag: Wiley-VCH Verlag GmbH & Co |
2008 | |
52 |
The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum Christoph Gelhaus, Thomas Jacobs, Jörg Andrä , Matthias Leippe Antimicrobial Agents and Chemotherapy 52, 1713-1720 (2008) |
51 |
Structure and mode of action of the antimicrobial peptide arenicin Jörg Andrä , Igor Jakovkin, Joachim Grötzinger, Oliver Hecht, Anna D. Krasnosdembskaya, Torsten Goldmann, Thomas Gutsmann , Matthias Leippe Biochemical Journal 410, 113-122 (2008) |
50 |
Interfacial properties and structural analysis of the antimicrobial peptide NK-2 Claudia Olak, Annabel Muenter, Jörg Andrä , Gerald Brezesinski Journal of Peptide Science 14, 510-517 (2008) |
49 |
Surface Acoustic Wave Biosensor as a Tool to Study the Interaction of Antimicrobial Peptides with Phospholipid and Lipopolysaccharide Model Membranes Jörg Andrä , Arne Böhling, Thomas M. A. Gronewold, Ulrich Schlecht, Markus Perpeet, Thomas Gutsmann Langmuir 24, 9148-9153 (2008) |
48 |
Antimicrobial peptides Sylvie E. Blondelle, Roman Jerala, Primoz Pristovsek, Andreja Majerle, Mateja Zorko, Bostjan Japelj, Klaus Brandenburg , Jörg Andrä , Massimo Porro, Ignacio Moriyón Uría, José Leiva León, Guillermo Martinez de Tejada, Dagmar Zweytick, Günter Deutsch, Karl Lohner Patent: WO 2008006125 (A1) 2008-01-17 |
2007 | |
47 |
Spectroscopic investigations into inactivation of bacterial virulence factors Klaus Brandenburg , Jörg Howe, Manfred Rössle, Jörg Andrä ACS Symposium Series 963 (New Approaches in Biomedical Spectroscopy) 410-420 (2007) |
46 |
Novel antiinflammatory and antiinfective agents Patrick Garidel , Jörg Andrä , Jörg Howe, Thomas Gutsmann , Klaus Brandenburg Anti-Infective Agents in Medicinal Chemistry 6, 185-200 (2007) |
45 |
Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis Jörg Andrä , Jörg Howe, Patrick Garidel , Manfred Rössle, Walter Richter, José Leiva León, Ignacio Moriyón, Rainer Bartels, Thomas Gutsmann , Klaus Brandenburg Biochemical Journal 406, 297-307 (2007) |
44 |
Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins Xi Chen, Jörg Howe, Jörg Andrä , Manfred Rössle, Walter Richter, Ana Paula Galvao da Silva, Alan M. Krensky, Carol Clayberger, Klaus Brandenburg Biochimica et Biophysica Acta, Biomembranes 1768, 2421-2431 (2007) |
43 |
Thermodynamic analysis of the lipopolysaccharide-dependent resistance of Gram-negative bacteria against polymyxin B Jörg Howe, Jörg Andrä , Raquel Conde, Maite Iriarte, Patrick Garidel , Michel H. J. Koch, Thomas Gutsmann , Ignacio Moriyón, Klaus Brandenburg Biophysical Journal 92, 2796-2805 (2007) |
42 |
Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens Jörg Andrä , Daniel Monreal, Guillermo Martinez de Tejada, Claudia Olak, Gerald Brezesinski, Susana Sánchez-Gómez, Torsten Goldmann, Rainer Bartels, Klaus Brandenburg , Ignacio Moriyón Journal of Biological Chemistry 282, 14719-14728 (2007) |
41 |
The Acyl Group as the Central Element of the Structural Organization of Antimicrobial Lipopeptide Bostjan Japelj, Mateja Zorko, Andreja Majerle, Primoz Pristovsek, Susana Sánchez-Gómez, Guillermo Martinez de Tejada, Ignacio Moriyón, Sylvie E. Blondelle, Klaus Brandenburg , Jörg Andrä , Karl Lohner, Roman Jerala Journal of the American Chemical Society 129, 1022-1023 (2007) |
2006 | |
40 |
Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity Dagmar Zweytick, Georg Pabst, Peter M. Abuja, Alexander Jilek, Sylvie E. Blondelle, Jörg Andrä , Roman Jerala, Daniel Monreal, Guillermo Martinez de Tejada, Karl Lohner Biochimica et Biophysica Acta, Biomembranes 1758, 1426-1435 (2006) |
39 |
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization Jörg Andrä , Jörg Rademann, Jörg Howe, Michel H. J. Koch, Holger Heine, Ulrich Zähringer, Klaus Brandenburg Biological Chemistry 387, 301-310 (2006) |
38 |
Dissection of the mechanisms of cytolytic and antibacterial activity of lysenin, a defence protein of the annelid Eisenia fetida Heike Bruhn, Julia Winkelmann, Christian Andersen, Jörg Andrä , Matthias Leippe Developmental & Comparative Immunology 30, 597-606 (2006) |
37 |
Biophysical characterization of synthetic rhamnolipids Jörg Howe, Jörg Bauer, Jörg Andrä , Andra B. Schromm, Martin Ernst, Manfred Rössle, Ulrich Zähringer, Jörg Rademann, Klaus Brandenburg FEBS Journal 273, 5101-5112 (2006) |
36 |
Mechanisms of endotoxin neutralization by synthetic cationic compounds Jörg Andrä , Thomas Gutsmann , Patrick Garidel , Klaus Brandenburg Journal of Endotoxin Research 12, 261-277 (2006) |
35 |
What can calorimetry tell us about changes of three-dimensional aggregate structures of phospholipids and glycolipids? Klaus Brandenburg , Patrick Garidel , Jörg Howe, Jörg Andrä , L. Hawkins, Michel H. J. Koch, Ulrich Seydel Thermochimica Acta 445, 133-143 (2006) |
2005 | |
34 |
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide Jörg Andrä , Karl Lohner, Sylvie E. Blondelle, Roman Jerala, Ignacio Moriyón, Michel H. J. Koch, Patrick Garidel , Klaus Brandenburg Biochemical Journal 385, 135-143 (2005) |
33 |
Structural rearrangement of model membranes by the peptide antibiotic NK-2 Regine Willumeit , Mont Kumpugdee, Sergio S. Funari, Karl Lohner, Beatriz Pozo Navas, Klaus Brandenburg , Sebastian Linser, Jörg Andrä Biochimica et Biophysica Acta, Biomembranes 1669, 125-134 (2005) |
32 |
Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity Patrick Garidel , Michael Rappolt, Andra B. Schromm, Jörg Howe, Karl Lohner, Jörg Andrä , Michel H. J. Koch, Klaus Brandenburg Biochimica et Biophysica Acta, Biomembranes 1715, 122-131 (2005) |
31 |
Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide Klaus Brandenburg , Alexander David, Jörg Howe, Michel H. J. Koch, Jörg Andrä , Patrick Garidel Biophysical Journal 88, 1845-1858 (2005) |
30 |
Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part II. Mesomorphic properties Götz Milkereit, Klaus Brandenburg , Sven Gerber, Michel H. J. Koch, Michael Morr, Jörg Andrä , Ulrich Seydel, Volkmar Vill Chemistry and Physics of Lipids 135, 15-26 (2005) |
29 |
Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes Klaus Brandenburg , Patrick Garidel , Andra B. Schromm, Jörg Andrä , Arjen Kramer, Maarten Egmond, Andre Wiese European Biophysics Journal 34, 28-41 (2005) |
28 |
Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity Ulrich Seydel, Andra B. Schromm, Lore Brade, Sabine Gronow, Jörg Andrä , Mareike Müller, Michel H. J. Koch, Koichi Fukase, Mikayo Kataoka, Masaya Hashimoto, Shoichi Kusumoto, Klaus Brandenburg FEBS Journal 272, 327-340 (2005) |
27 |
The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine Hannah Schröder-Borm, Rumiana Bakalova, Jörg Andrä FEBS Letters 579, 6128-6134 (2005) |
26 |
Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection Thomas Jacobs, Jörg Andrä , Iris Gaworski, Sebastian Graefe, Katja Mellenthin, Manfred Krömer, Roman Halter, Jürgen Borlak, Joachim Clos Medical Microbiology and Immunology 194, 143-149 (2005) |
25 |
Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: Physicochemical characterization and biological activity Jörg Andrä , Hans de Cock, Patrick Garidel , Jörg Howe, Klaus Brandenburg Medicinal Chemistry 1, 537-546 (2005) |
24 |
Die duale Funktion von Antimikrobiellen Peptiden: Antibiotische Wirkung und Endotoxin Neutralisierung. Von den molekularen Mechanismen zur Wirkstoffentwicklung Jörg Andrä Habilitationsschrift, Hamburg (2005) |
2004 | |
23 |
Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin Jörg Andrä , Michel H. J. Koch, Rainer Bartels, Klaus Brandenburg Antimicrobial Agents and Chemotherapy 48, 1593-1599 (2004) |
22 |
Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide Jörg Andrä , Marta Lamata, Guillermo Martinez de Tejada, Rainer Bartels, Michel H. J. Koch, Klaus Brandenburg Biochemical Pharmacology 68, 1297-1307 (2004) |
21 |
Structural Polymorphism and Endotoxic Activity of Synthetic Phospholipid-like Amphiphiles Klaus Brandenburg , L. Hawkins, Patrick Garidel , Jörg Andrä , Mareike Müller, Holger Heine, Michel H. J. Koch, Ulrich Seydel Biochemistry 43, 4039-4046 (2004) |
20 |
Physicochemical characterization of the endotoxins from Coxiella burnetii strain Priscilla in relation to their bioactivities Rudolf Toman, Patrick Garidel , Jörg Andrä , Katarina Slaba, Ahmed Hussein, Michel H. J. Koch, Klaus Brandenburg BMC Biochemistry 5, 1-11 (2004) |
19 |
Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide Jörg Andrä , Patrick Garidel , Andreja Majerle, Roman Jerala, Richard Ridge, Erik Paus, Tom Novitsky, Michel H. J. Koch, Klaus Brandenburg European Journal of Biochemistry 271, 2037-2046 (2004) |
18 |
Membrane lipid composition protects Entamoeba histolytica from self-destruction by its pore-forming toxins Jörg Andrä , Otto Berninghausen, Matthias Leippe FEBS Letters 564, 109-115 (2004) |
17 |
Complement Inactivation by Recombinant Human C3 Derivatives Johanna Kölln, Edzard Spillner , Jörg Andrä , Katrin Klensang, Reinhard Bredehorst Journal of Immunology 173, 5540-5545 (2004) |
2003 | |
16 |
Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin Hannah Schröder-Borm, Regine Willumeit , Klaus Brandenburg , Jörg Andrä Biochimica et Biophysica Acta, Biomembranes 1612, 164-171 (2003) |
15 |
Physicochemical properties of bacterial glycopolymers in relation to bioactivity Klaus Brandenburg , Jörg Andrä , Mareike Müller, Michel H. J. Koch, Patrick Garidel Carbohydrate Research 338, 2477-2489 (2003) |
14 |
Amoebapores, archaic effector peptides of protozoan origin, are discharged into phagosomes and kill bacteria by permeabilizing their membranes Jörg Andrä , Rosa Herbst, Matthias Leippe Developmental & Comparative Immunology 27, 291-304 (2003) |
13 |
Physicochemical
characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans Klaus Brandenburg , Frauke Wagner, Mareike Müller, Holger Heine, Jörg Andrä , Michel H. J. Koch, Ulrich Zähringer, Ulrich Seydel European Journal of Biochemistry 270, 3271-3279 (2003) |
12 |
Cross-linked Hemoglobin Converts Endotoxically Inactive Pentaacyl Endotoxins into a Physiologically Active Conformation Klaus Brandenburg , Patrick Garidel , Jörg Andrä , Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H. J. Koch, Jack Levin Journal of Biological Chemistry 278, 47660-47669 (2003) |
2002 | |
11 |
Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins Klaus Brandenburg , Gudrun Jürgens, Jörg Andrä , Buko Lindner, Michel H. J. Koch, Alfred Blume, Patrick Garidel European Journal of Biochemistry 269, 5972-5981 (2002) |
10 |
Generation and characterization of transgenic mice expressing cobra venom factor Jörg Andrä , Roman Halter, Michael A. Kock, Heiner Niemann, Carl-Wilhelm Vogel, Dieter Paul Molecular Immunology 39, 357-365 (2002) |
2001 | |
9 |
Cecropins, antibacterial peptides from insects and mammals, are potently fungicidal against Candida albicans Jörg Andrä , Otto Berninghausen, Matthias Leippe Medical Microbiology and Immunology 189, 169-173 (2001) |
1999 | |
8 |
Candidacidal activity of shortened synthetic analogs of amoebapores and NK-lysin Jörg Andrä , Matthias Leippe Medical Microbiology and Immunology 188, 117-124 (1999) |
1997 | |
7 |
Molecular basis of aggressive and defensive functions of Entamoeba histolytica Claudia Benkert, Thomas Jacobs, Otto Berninghausen, Jörg Andrä , Matthias Leippe Archives of Medical Research 28 (Spec. Issue) 152-153 (1997) |
6 |
Potency of amoebapores compared to that of other membrane-permeating peptides Jörg Andrä , Otto Berninghausen, Matthias Leippe Archives of Medical Research 28 (Spec. Issue) 156-157 (1997) |
1996 | |
5 |
Shortened amoebapore analogs with enhanced antibacterial and cytolytic activity Jörg Andrä , Otto Berninghausen, Jan Wülfken, Matthias Leippe FEBS Letters 365, 96-100 (1996) |
4 |
Amoebapores, cytolytische und antibakterielle Peptide aus Entamoeba histolytica. Untersuchung der Struktur-Funktionsbeziehungen Jörg Andrä (= Jörg Peter Andrä) -/- Betreuer: Matthias Leippe Dissertation, Hamburg (1996) |
1994 | |
3 |
Pore-forming peptide of Entamoeba histolytica. Significance of positively charged amino acid residues for its mode of action Jörg Andrä , Matthias Leippe FEBS Letters 354, 97-102 (1994) |
2 |
Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes Matthias Leippe, Jörg Andrä , Rose Nickel, Egbert Tannich, Hans J. Müller-Eberhard Molecular Microbiology 14, 895-904 (1994) |
1 |
Cytolytic and antibacterial activity of synthetic peptides derived from amoebapore, the pore-forming peptide of Entamoeba histolytica Matthias Leippe, Jörg Andrä , Hans J. Müller-Eberhard Proceedings of the National Academy of Sciences of the United States of America 91, 2602-2606 (1994) |