Fachbereich Chemie
Publikationen von Tobias Gräwert
Herr Gräwert war vom 2011 bis 2014 Wissenschaftlicher Mitarbeiter im Institut für Lebensmittelchemie der Universität Hamburg.
.
| Suche: FB Chemie / Hamburg | |
| 2019 | |
| 30 |
Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target Sonja Schüssler, Ilka Haase, Markus Perbandt , Boris A. Illarionov , Alexandra Siemens, Klaus Richter, Adelbert Bacher , Markus Fischer , Tobias Gräwert Acta Crystallographica, Section F: Structural Biology Communications 75, 586-592 (2019) |
| 29 |
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity Claudia Lienau, Tobias Gräwert , Leandro A. Alves Avelar, Boris A. Illarionov , Jana Held, Tanja C. Knaab, Beate Lungerich, Lasse van Geelen, Dieter Meier, Stefanie Geissler, Holger Cynis, Ulrich Riederer, Mirko Buchholz, Rainer Kalscheuer, Adelbert Bacher , Benjamin Mordmüller, Markus Fischer , Thomas Kurz European Journal of Medicinal Chemistry 181, 111555 (2019) |
2018 | |
| 28 |
Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor Katharina Root, Konstantin Barylyuk, Anatol Schwab, Jonas Thelemann, Boris A. Illarionov , Julie G. Geist, Tobias Gräwert , Adelbert Bacher , Markus Fischer , François Diederich, Renato Zenobi Chemical Science 9, 5976-5986 (2018) |
2015 | |
| 27 |
The complex isotopologue space of glucose as a framework for the study of human intermediary metabolism Silke Marsch, Adelbert Bacher , Christian Ettenhuber, Tobias Gräwert , Harald Mückter, Dietrich Seidel, Michael Vogeser, Ralf Laupitz, Markus Fischer , Ulrike Bacher, Wolfgang Eisenreich Isotopes in Environmental and Health Studies 51, 11-23 (2015) |
| 26 |
Prodrugs of reverse fosmidomycin analogs Karin Brücher, Tobias Gräwert , Sarah Konzuch, Jana Held, Claudia Lienau, Christoph Timon Behrendt, Boris A. Illarionov , Louis Maes, Adelbert Bacher , Sergio Wittlin, Benjamin Mordmüller, Markus Fischer , Thomas Kurz Journal of Medicinal Chemistry 58, 2025-2035 (2015) |
| 25 |
Inhibition of the Non-Mevalonate Isoprenoid Pathway by Reverse Hydroxamate Analogues of Fosmidomycin Claudia Lienau, Sarah Konzuch, Tobias Gräwert , Boris A. Illarionov , Adelbert Bacher , Markus Fischer , Nobutada Tanaka, Thomas Kurz Procedia Chemistry 14, 108-116 (2015) |
2014 | |
| 24 |
Inhibition of Methyl-CoM Reductase from Methanobrevibacter ruminantium by 2-Bromoethanesulfonate Tobias Gräwert , Hans-Peter Hohmann, Maik Kindermann, Stephane Duval, Adelbert Bacher , Markus Fischer Journal of Agricultural and Food Chemistry 62, 12487-12490 (2014) |
| 23 |
Binding modes of reverse fosmidomycin analogs towards the antimalarial target IspC Sarah Konzuch, Tomonobu Umeda, Jana Held, Saskia Hähn, Karin Brücher, Claudia Lienau, Christoph Timon Behrendt, Tobias Gräwert , Adelbert Bacher , Boris A. Illarionov , Markus Fischer , Benjamin Mordmüller, Nobutada Tanaka, Thomas Kurz Journal of Medicinal Chemistry 57, 8827-8838 (2014) |
| 22 |
Recent Advances in Riboflavin Biosynthesis Ilka Haase, Tobias Gräwert , Boris A. Illarionov , Adelbert Bacher , Markus Fischer -/- Herausgeber: Stefan Weber, Erik Schleicher Methods in Molecular Biology 1146 (Flavins and Flavoproteins) 15-40 (2014) |
2013 | |
| 21 |
Structures and reaction mechanisms of GTP cyclohydrolases Tobias Gräwert , Markus Fischer , Adelbert Bacher IUBMB Life 65, 310-322 (2013) |
| 20 |
IspC as target for antiinfective drug discovery: Synthesis, enantiomeric separation and structural biology of fosmidomycin thia-isosters Andrea Kunfermann, Claudia Lienau, Boris A. Illarionov , Jana Held, Tobias Gräwert , Christoph Timon Behrendt, Philipp Werner, Saskia Hähn, Wolfgang Eisenreich, Ulrich Riederer, Benjamin Mordmüller, Adelbert Bacher , Markus Fischer , Michael Groll, Thomas Kurz Journal of Medicinal Chemistry 56, 8151-8162 (2013) |
2012 | |
| 19 |
α-Substituted β-oxa Isosteres of Fosmidomycin: Synthesis and biological evaluation Karin Brücher, Boris A. Illarionov , Jana Held, Serena Tschan, Andrea Kunfermann, Miriam K. Pein, Adelbert Bacher , Tobias Gräwert , Louis Maes, Benjamin Mordmüller, Markus Fischer , Thomas Kurz Journal of Medicinal Chemistry 55, 6566-6575 (2012) |
| 18 |
Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis Ingrid Span, Tobias Gräwert , Adelbert Bacher , Wolfgang Eisenreich, Michael Groll Journal of Molecular Biology 416, 1-9 (2012) |
2011 | |
| 17 |
Biochemistry of the non-mevalonate isoprenoid pathway Tobias Gräwert , Michael Groll, Felix Rohdich, Adelbert Bacher , Wolfgang Eisenreich Cellular and Molecular Life Sciences 68, 3797-3814 (2011) |
| 16 |
Reverse
Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr) Christoph Timon Behrendt, Andrea Kunfermann, Victoria A. Illarionova, An Matheeussen, Miriam K. Pein, Tobias Gräwert , Johannes Kaiser, Adelbert Bacher , Wolfgang Eisenreich, Boris A. Illarionov , Markus Fischer , Louis Maes, Michael Groll, Thomas Kurz Journal of Medicinal Chemistry 54, 6796-6802 (2011) |
2010 | |
| 15 |
Reductive dehydroxylation of allyl alcohols by IspH protein Tobias Gräwert , Ingrid Span, Adelbert Bacher , Michael Groll Angewandte Chemie, International Edition 49, 8802-8809 (2010) |
| 14 |
Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum Julie G. Geist, Susan Lauw, Victoria A. Illarionova, Boris A. Illarionov , Markus Fischer , Tobias Gräwert , Felix Rohdich, Wolfgang Eisenreich, Johannes Kaiser, Michael Groll, Christian Scheurer, Sergio Wittlin, Jose L. Alonso-Gomez, W. Bernd Schweizer, Adelbert Bacher , François Diederich ChemMedChem 5, 1092-1101 (2010) |
| 13 |
Synthesis and antiplasmodial activity of highly active reverse analogs of the antimalarial drug candidate Fosmidomycin Christoph Timon Behrendt, Andrea Kunfermann, Victoria A. Illarionova, An Matheeussen, Tobias Gräwert , Michael Groll, Felix Rohdich, Adelbert Bacher , Wolfgang Eisenreich, Markus Fischer , Louis Maes, Thomas Kurz ChemMedChem 5, 1673-1676 (2010) |
| 12 |
Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe-4S] Cluster Protein IspG Matthias Lee, Tobias Gräwert , Felix Quitterer, Felix Rohdich, Jörg Eppinger, Wolfgang Eisenreich, Adelbert Bacher , Michael Groll Journal of Molecular Biology 404, 600-610 (2010) |
| 11 |
Probing the reaction mechanism of IspH protein by x-ray structure analysis Tobias Gräwert , Ingrid Span, Wolfgang Eisenreich, Felix Rohdich, Jörg Eppinger, Adelbert Bacher , Michael Groll Proceedings of the National Academy of Sciences of the United States of America 107, 1077-1081 (2010) |
2009 | |
| 10 |
Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction Tobias Gräwert , Felix Rohdich, Ingrid Span, Adelbert Bacher , Wolfgang Eisenreich, Jörg Eppinger, Michael Groll Angewandte Chemie, International Edition 48, 5756-5759 (2009) |
| 9 |
Manufacture of of isoprenoids with microorganisms expressing plant genes for enzymes of isoprenoid biosynthesis Volker Sieber, Johannes Kaiser, Broder Rühmann, Nicole Potgrave, Eva-Maria Wittmann, Achim Marx, Norbert Windhab, Christian Ewering, Jens Kroll, Christian Schulze Gronover, Dirk Prüfer, Alexander Steinbüchel, David Wurbs, Adelbert Bacher , Wolfgang Eisenreich, Tobias Gräwert , Victoria A. Illarionova, Michael Groll, Felix Rohdich -/- Anmelder: Evonik Degussa GmbH Patent: WO 2009030654 (A1) 2009-03-12; DE 102007041862 (A1) 2009-03-19 |
2006 | |
| 8 |
IspH-Protein aus Escherichia coli und IspDF-Protein aus Campylobacter jejuni. Untersuchung und Charakterisierung Tobias Gräwert (= Tobias Wilhelm Gräwert) -/- Betreuer: Adelbert Bacher Dissertation, München (2006) |
2005 | |
| 7 |
Biosynthesis of Isoprenoids. Purification and Properties of IspG Protein from Escherichia coli Ferdinand Zepeck, Tobias Gräwert , Johannes Kaiser, Nicholas Schramek, Wolfgang Eisenreich, Adelbert Bacher , Felix Rohdich Journal of Organic Chemistry 70, 9168-9174 (2005) |
2004 | |
| 6 |
Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems Ralf Laupitz, Tobias Gräwert , Christoph Rieder, Ferdinand Zepeck, Adelbert Bacher , Duilio Arigoni, Felix Rohdich, Wolfgang Eisenreich Chemistry & Biodiversity 1 (9) 1367-1376 (2004) Erratum: Chemistry & Biodiversity 1, 1854-1854 (2004) |
| 5 |
Biosynthesis of isoprenoids. A bifunctional IspDF enzyme from Campylobacter jejuni Mads Gabrielsen, Felix Rohdich, Wolfgang Eisenreich, Tobias Gräwert , Stefan Hecht, Adelbert Bacher , William N. Hunter European Journal of Biochemistry 271, 3028-3035 (2004) |
| 4 |
IspH Protein of Escherichia coli: Studies on Iron-Sulfur Cluster Implementation and Catalysis Tobias Gräwert , Johannes Kaiser, Ferdinand Zepeck, Ralf Laupitz, Stefan Hecht, Sabine Amslinger, Nicholas Schramek, Erik Schleicher, Stefan Weber, Martin Haslbeck, Johannes Buchner, Christoph Rieder, Duilio Arigoni, Adelbert Bacher , Wolfgang Eisenreich, Felix Rohdich Journal of the American Chemical Society 126, 12847-12855 (2004) |
| 3 |
Assays for identifying inhibitors of gene ispH 1-hydroxy-2-methyl-(E)-butenyl-4-diphosphate reductase Petra Adam, Adelbert Bacher , Wolfgang Eisenreich, Tobias Gräwert , Stefan Hecht, Felix Rohdich, Ferdinand Zepeck Patent: DE 10302370 (A1) 2004-08-05 |
2003 | |
| 2 |
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and isph protein Felix Rohdich, Ferdinand Zepeck, Petra Adam, Stefan Hecht, Johannes Kaiser, Ralf Laupitz, Tobias Gräwert , Sabine Amslinger, Wolfgang Eisenreich, Adelbert Bacher , Duilio Arigoni Proceedings of the National Academy of Sciences of the United States of America 100, 1586-1591 (2003) |
2002 | |
| 1 |
Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase Petra Adam, Stefan Hecht, Wolfgang Eisenreich, Johannes Kaiser, Tobias Gräwert , Duilio Arigoni, Adelbert Bacher , Felix Rohdich Proceedings of the National Academy of Sciences of the United States of America 99, 12108-12113 (2002) |